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首页> 外文期刊>Journal of Reproductive Immunology >Differences in circulating dendritic cell subtypes in peripheral, placental and cord blood in African pregnant women.
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Differences in circulating dendritic cell subtypes in peripheral, placental and cord blood in African pregnant women.

机译：非洲孕妇外周血，胎盘和脐带血中循环树突状细胞亚型的差异。

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摘要

Dendritic cells (DC) are important for induction of primary immune responses and immunological tolerance. Changes in the frequency of DC subsets were analyzed in peripheral blood from pregnant women (mPB) and compared to placental blood (PB) and cord blood (CB). DCs were identified by flow cytometry in whole blood as lineage negative and HLA-DR-positive cells. Different DC subtypes were identified with CD123 and CD11c markers. In these data, the percentage of DC was significantly lower in mPB, PB and CB than in control women, but the absolute number of DC was higher in CB, suggesting that numbers of DC in CB do not explain the decrease of the immune response in newborn infants. Myeloid DCs (MDC) decreased in all compartments of pregnant women compared to control women, especially in mPB where MDC became lower than lymphoid DCs. An increase of less differentiated DC was observed in mPB and CB from pregnant women. DCs in pregnant women were mainly immature DC with a proportion of CD83-positive DC, identical as control women. The levels of IFNgamma, TNFalpha, IL-2, IL-4, IL-5 and IL-10 were not different in the three compartments (mPB, PB, CB). In conclusion, the phenotype and subset of DCs were different in pregnant women than in control women, suggesting a role in maintenance of immune tolerance against the fetus. The distribution of DC subsets was different in mPB, PB and CB. Their role in the regulation of immune response remains to be elicited.
机译：树突状细胞（DC）对于诱导初次免疫反应和免疫耐受性很重要。分析孕妇外周血（mPB）中DC亚群频率的变化，并将其与胎盘血（PB）和脐带血（CB）进行比较。通过流式细胞术在全血中将DC鉴定为谱系阴性和HLA-DR阳性细胞。用CD123和CD11c标记鉴定了不同的DC亚型。在这些数据中，mPB，PB和CB中DC的百分比显着低于对照女性，但CB中DC的绝对数量较高，这表明CB中DC的数量不能解释免疫应答的降低。新生婴儿。与对照组女性相比，孕妇所有部位的髓样DC（MDC）均下降，尤其是在mPB中，MDC低于淋巴样DC。孕妇的mPB和CB中分化程度较低的DC有所增加。孕妇中的DC主要为未成熟DC，其CD83阳性DC的比例与对照女性相同。在三个部分（mPB，PB，CB）中，IFNgamma，TNFα，IL-2，IL-4，IL-5和IL-10的水平没有差异。总之，孕妇的DC的表型和子集与对照组的妇女不同，这表明在维持针对胎儿的免疫耐受性中起作用。 DC子集的分布在mPB，PB和CB中有所不同。它们在调节免疫应答中的作用尚待阐明。

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