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首页> 外文期刊>Journal of Reproductive Immunology >Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients.
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Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients.

机译：原因不明的反复自然流产患者外周血和蜕膜中T辅助17（Th17）细胞的患病率增加。

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摘要

T helper 17 (Th17) cells and regulatory T (Treg) cells are two distinct subsets of CD4(+) T cells which have opposite effects on inflammation, autoimmunity and immunological rejection of foreign tissue. Treg cells have been shown to be important in maintaining materno-fetal tolerance, but the role of Th17 cells in human pregnancy and pathological pregnancy, especially in relation to unexplained recurrent spontaneous abortion (RSA), has not been investigated. In this study, we showed that the proportion of Th17 cells in the peripheral blood and decidua was significantly higher in unexplained RSA patients compared to normal, early pregnant women. Meanwhile, there was an inverse relationship between Th17 cells and Treg cells in the peripheral blood lymphocytes (PBL) and decidua in unexplained RSA. The expression of Th17 related factors, IL-17, IL-23 and retinoid orphan nuclear receptor (RORC), in PBL and decidua in unexplained RSA patients was significantly higher than normal, early pregnant women. This study is the first to define the occurrence of Th17 cells in unexplained RSA patients and in normal, early pregnant women. We suggest that these highly pro-inflammatory cells contribute to unexplained RSA, and the balance between Th17 cells and Treg cells may be critical to pregnancy outcomes.
机译：T辅助细胞17（Th17）和调节性T（Treg）细胞是CD4（+）T细胞的两个不同子集，它们对炎症，自身免疫和异物组织的免疫排斥具有相反的作用。已经显示Treg细胞在维持胎儿耐受性中很重要，但是尚未研究Th17细胞在人妊娠和病理性妊娠中的作用，特别是与无法解释的反复自然流产（RSA）有关。在这项研究中，我们表明，与正常的早期孕妇相比，无法解释的RSA患者外周血和蜕膜中Th17细胞的比例明显更高。同时，原因不明的RSA中外周血淋巴细胞（PBL）中的Th17细胞和Treg细胞与蜕膜之间存在反比关系。 Th17相关因子，IL-17，IL-23和类维生素A孤儿核受体（RORC）在无法解释的RSA患者中的PBL和蜕膜中的表达明显高于正常的早期孕妇。该研究首次确定了无法解释的RSA患者和正常早期孕妇中Th17细胞的发生。我们建议这些高度促炎的细胞导致无法解释的RSA，Th17细胞和Treg细胞之间的平衡可能对妊娠结局至关重要。

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