...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >Dydrogesterone supplementation in women with threatened preterm delivery--the impact on cytokine profile, hormone profile, and progesterone-induced blocking factor.
【24h】

Dydrogesterone supplementation in women with threatened preterm delivery--the impact on cytokine profile, hormone profile, and progesterone-induced blocking factor.

机译：早产受到威胁的女性中补充孕酮-对细胞因子谱，激素谱和孕激素诱导的阻断因子的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Progesterone is indispensable in creating a suitable endometrial environment for implantation, and also for the maintenance of pregnancy. Successful pregnancy depends on an appropriate maternal immune response to the fetus. A protein called progesterone-induced blocking factor (PIBF) acts by inducing Th2-dominant cytokine production to mediate the immunological effects of progesterone. The aim of this prospective study was to compare serum concentrations of progesterone (P), estradiol (E2), anti-inflammatory (IL-10) and pro-inflammatory (IL-6, TNFalpha, IFNgamma) cytokines, and serum PIBF concentrations in women with threatened preterm delivery who were given progesterone supplementation (study group) with those of women with threatened preterm delivery who were not given progesterone supplementation (control group). After dydrogesterone treatment of patients in the study group, serum PIBF as well as progesterone concentrations significantly increased. Women in this group had significantly higher serum levels of IL-10 than controls. The length of gestation was significantly higher in the group of women who were given progesterone supplementation. Our data suggest that dydrogesterone treatment of women at risk of preterm delivery results in increased PIBF production and IL-10 concentrations, and lower concentrations of IFNgamma.
机译：孕酮在创造合适的子宫内膜环境以进行植入以及维持妊娠方面必不可少。成功怀孕取决于适当的母体对胎儿的免疫反应。一种称为孕激素诱导的阻断因子（PIBF）的蛋白通过诱导Th2占主导的细胞因子产生来介导孕激素的免疫学作用。这项前瞻性研究的目的是比较血清孕激素（P），雌二醇（E2），抗炎（IL-10）和促炎（IL-6，TNFalpha，IFNgamma）细胞因子的浓度，以及血清PIBF的浓度。威胁早产的妇女接受孕激素补充（研究组）和威胁早产的妇女未接受孕激素补充（对照组）。在研究组中使用去氢孕酮治疗的患者后，血清PIBF和孕酮浓度显着增加。该组女性的血清IL-10水平明显高于对照组。在补充孕激素的女性中，妊娠时间明显更长。我们的数据表明，使用dydrogesterone治疗有早产风险的妇女会导致PIBF产生增加和IL-10浓度升高，IFNγ浓度降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号