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首页> 外文期刊>Journal of Reproductive Immunology >Inositol phosphoglycans and preeclampsia: from bench to bedside.
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Inositol phosphoglycans and preeclampsia: from bench to bedside.

机译：肌醇磷酸聚糖和先兆子痫：从板凳到床边。

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摘要

The metabolic syndrome that occurs in preeclampsia reflects the complex interactions between immunological alterations and the systemic inflammation that have been shown to take place during this complication of human pregnancy. Inositol phosphoglycans play a definite role in the insulin resistance in preeclampsia with a higher production and urinary excretion of this molecule before and during preeclampsia. Recent researches suggest that the feto-placental glucose metabolism in the first and early second trimester is mainly linked to the nonoxidative pathway of glycogen catabolism supporting the pivotal role of the inositol phosphoglycan P-type. In this article we present the results of a case-control study carried out in the first trimester to evaluate the potential of urinary P-IPG release as a early marker of the disease. A single mid-stream sample of maternal urine was collected at 11 weeks of gestation for this single centre retrospective study. Twenty-seven patients out of 331 women recruited (8.1%) went on to develop preeclampsia but no sample attained positivity. Further details about the development of the metabolic syndrome during preeclampsia were retrieved also from other studies to implement our knowledge about the pathophysiology of this syndrome and to identify biochemical aspects that could help in clinical practice.
机译：先兆子痫中发生的代谢综合症反映了免疫变化和全身炎症之间的复杂相互作用，这种相互作用已显示在人类妊娠并发症中发生。肌醇磷酸聚糖在先兆子痫前期的胰岛素抵抗中起着确定的作用，在先兆子痫前和先兆期间，该分子具有更高的产量和尿液排泄量。最近的研究表明，胎儿-胎盘葡萄糖在孕早期和孕中期的代谢主要与糖原分解代谢的非氧化途径有关，从而支持了肌醇磷酸聚糖P型的关键作用。在本文中，我们介绍了在孕早期进行的病例对照研究的结果，以评估尿P-IPG释放作为疾病早期标志物的潜力。这项妊娠回顾研究在妊娠11周时收集了一个母体尿液的中间样本。在招募的331名妇女中，有27名患者（8.1％）继续发展先兆子痫，但没有样本达到阳性。还从其他研究中获得了子痫前期代谢综合征发展的更多详细信息，以实现我们对该综合征的病理生理学的认识，并确定可在临床实践中有所帮助的生化方面。

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