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首页> 外文期刊>Journal of Reproductive Immunology >Induction of circulating monocyte chemoattractant protein-1 in women with gonadotropin-releasing hormone agonist.
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Induction of circulating monocyte chemoattractant protein-1 in women with gonadotropin-releasing hormone agonist.

机译：促性腺激素释放激素激动剂对女性循环单核细胞趋化蛋白-1的诱导。

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摘要

The aim of the present study was to determine the influence of acute estrogen deficiency induced by administration of a gonadotropin-releasing hormone (GnRH) agonist on circulating levels of cytokines and chemokines. Eighty-three women with uterine leiomyoma were assigned in open, parallel-group fashion to a no-treatment (control) group and a GnRH-agonist group. Serum levels of nine cytokines and chemokines as well as vascular inflammatory markers were measured. Serum levels of monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor-alpha (TNFalpha) in the GnRH-agonist group were increased significantly at 6 months. There were also significant differences in percentage changes in interleukin (IL)-6, IL8, MCP1, and macrophage inflammatory protein-1beta (MIP1beta) between the control and GnRH agonist groups. Soluble intercellular adhesion molecule-1 (sICAM1) and E-selectin levels showed significant increases in the GnRH agonist group at 6 months. Serum MCP1 concentrations showed weak correlations with levels of sICAM and E-selectin. We conclude that a hypo-estrogenic state due to administration of a GnRH agonist increases circulating levels of cytokines and chemokines, especially MCP1.
机译：本研究的目的是确定给予促性腺激素释放激素（GnRH）激动剂引起的急性雌激素缺乏对细胞因子和趋化因子循环水平的影响。将八十三名子宫平滑肌瘤妇女以开放式，平行分组的方式分配至未治疗（对照组）和GnRH激动剂组。测量了九种细胞因子和趋化因子的血清水平以及血管炎性标志物。 GnRH激动剂组的单核细胞趋化蛋白（MCP）-1和肿瘤坏死因子-α（TNFα）的血清水平在6个月时显着增加。在对照组和GnRH激动剂组之间，白介素（IL）-6，IL8，MCP1和巨噬细胞炎性蛋白1beta（MIP1beta）的百分比变化也存在显着差异。在6个月时，GnRH激动剂组的可溶性细胞间粘附分子1（sICAM1）和E-选择素水平显着增加。血清MCP1浓度与sICAM和E-选择素水平呈弱相关性。我们得出的结论是，由于施用GnRH激动剂而导致的低雌激素状态会增加细胞因子和趋化因子（尤其是MCP1）的循环水平。

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