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Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor

机译：比较早产和足月分娩负责宫颈重塑的机制

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Understanding the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. Is preterm cervical remodeling caused by the same mechanisms that cause cervical remodeling at term, and are these changes accelerated in time? This question has been pondered by obstetricians seeking strategies to prevent preterm labor for many years. Mice represent an informative model of preterm birth. Thus, in this review we discuss the recent findings from mouse models that identify and characterize the initiators and cellular effectors of cervical remodeling at term and preterm labor/delivery. These studies suggest that similarities and differences exist between term and preterm cervical remodeling. Complement is an initiator or mediator in preterm labor/delivery, but is not involved in the physiological process that leads to term delivery. Therefore, complememt constitutes a specific and selective target for potentially preventing preterm delivery, thus improving neonatal health. ? 2012 Elsevier Ireland Ltd.
机译：了解足月和早产儿宫颈重塑的机制对于预防早产至关重要。早产儿子宫颈重塑是否由引起足月子宫颈重塑的相同机制引起，并且这些变化会随着时间加速吗？寻求预防早产的策略的产科医生已经思考了很多年。小鼠代表了早产的信息模型。因此，在这篇综述中，我们讨论了小鼠模型的最新发现，这些小鼠模型在足月和早产/分娩时鉴定并表征了宫颈重塑的引发剂和细胞效应子。这些研究表明足月和早产儿宫颈重塑之间存在相似性和差异。补体是早产/分娩的发起者或中介，但不参与导致足月分娩的生理过程。因此，comlememt构成了潜在预防早产的特定和选择性目标，从而改善了新生儿的健康状况。 ？ 2012爱思唯尔爱尔兰有限公司

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