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Markers of semen inflammation: Supplementary semen analysis?

机译:精液炎症标志物:补充精液分析?

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摘要

Understanding semen markers of inflammation is important for the diagnostic-therapeutic management of male infertility, particularly in patients with male accessory gland infection (MAGI). The aim of this article was to describe the major pathophysiological elements through which inflammation negatively affects sperm parameters. Inflammation may affect reproduction through one or more of the following mechanisms: anatomical alteration of the male accessory gland (e.g., obstruction or sub-obstruction); functional alteration of the male accessory gland, i.e., by inhibiting the production of adequate amounts of nutrients and/or by releasing compounds such as radical oxygen species (ROS) and cytokines that alter the microenvironment in which spermatozoa develop and mature; and/or direct negative effects on the spermatozoa (germ-spermatozoa interaction).
机译:了解炎症的精液标志物对于男性不育症的诊断治疗管理非常重要,尤其是在患有男性副腺感染(MAGI)的患者中。本文的目的是描述炎症对精子参数产生负面影响的主要病理生理因素。炎症可能通过以下一种或多种机制影响生殖:雄性副腺的解剖学改变(例如阻塞或亚阻塞);雄性副腺的功能性改变,即通过抑制产生足够量的养分和/或释放诸如自由基氧(ROS)和细胞因子的化合物来改变精子在其中发育和成熟的微环境;和/或对精子有直接的负面影响(细菌与精子的相互作用)。

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