• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Reproductive Immunology >Prevalence of coagulation factor XIII and plasminogen activator inhibitor-1 gene polymorphisms among Egyptian women suffering from unexplained primary recurrent miscarriage
【24h】

Prevalence of coagulation factor XIII and plasminogen activator inhibitor-1 gene polymorphisms among Egyptian women suffering from unexplained primary recurrent miscarriage

机译：患有无法解释的原发性反复流产的埃及妇女中凝血因子XIII和纤溶酶原激活物抑制剂-1基因多态性的患病率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recurrent miscarriage (RM) is an obstetric challenge. Polymorphisms of factor XIII (FXIII) and plasminogen activator inhibitor-1 (PAI-1) may cause an imbalance between coagulation and fibrinolysis that can end in RM. The aim of the work was to determine the prevalence of FXIII Val34Leu and PAI-1 4G/5G gene polymorphisms in Egyptian women presenting with unexplained primary first trimester RM. Genotyping of 120 unexplained primary first trimester RM patients and 130 healthy controls by polymerase chain reaction (PCR) amplification of target genes followed by the allele-specific restriction enzyme digestion (RFLP technique). Among the cases, 67.5% of individuals had wild-type FXIII; 21.7% were heterozygous and 10.8% were homozygous for the FXIII Val34Leu polymorphism. Among controls, the proportions were 89.2%, 8.5% and 2.3% respectively. In addition, comparison between the two groups regarding Leu and 4G allele frequencies showed statistically significant differences (P values = 0.0001 and 0.027 respectively). RM is more frequent in women with combined polymorphisms than in women with a single gene polymorphism (RR=3.91;OR-4.51; 95% CI = 1.79-11.38; P= 0.002). FXIII Val34Leu and PAI-1 4G/5G polymorphisms are prevalent in Egyptian women, with unexplained primary first trimester RM and combined polymorphisms statistically increasing the risk.
机译：反复流产（RM）是一个产科挑战。 XIII因子（FXIII）和纤溶酶原激活物抑制剂1（PAI-1）的多态性可能会导致凝血和纤维蛋白溶解之间的不平衡，最终导致RM。这项工作的目的是确定存在无法解释的原发性早孕RM的埃及女性中FXIII Val34Leu和PAI-1 4G / 5G基因多态性的患病率。通过对目标基因进行聚合酶链反应（PCR）扩增，然后进行等位基因特异性限制性酶切消化（RFLP技术），对120名无法解释的原发性早孕RM患者和130名健康对照进行基因分型。在这些病例中，有67.5％的个体患有野生型FXIII; FXIII Val34Leu多态性的杂合子为21.7％，纯合子为10.8％。在对照组中，比例分别为89.2％，8.5％和2.3％。此外，两组之间关于Leu和4G等位基因频率的比较显示出统计学上的显着差异（P值分别为0.0001和0.027）。合并多态性的女性比单基因多态性的女性更常见（RR = 3.91; OR-4.51; 95％CI = 1.79-11.38; P = 0.002）。 FXIII Val34Leu和PAI-1 4G / 5G多态性在埃及女性中普遍存在，原因不明的孕早期RM和组合多态性在统计学上增加了患病风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号