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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >New developments providing mechanistic insight into the impact of the microbiota on allergic disease
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New developments providing mechanistic insight into the impact of the microbiota on allergic disease

机译：新的发展提供了对微生物群对过敏性疾病影响的机械观察

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摘要

The increase in allergic diseases over the past several decades is correlated with changes in the composition and diversity of the intestinal microbiota. Microbial-derived signals are critical for instructing the developing immune system and conversely, immune regulation can impact the microbiota. Perturbations in the microbiota composition may be especially important during early-life when the immune system is still developing, resulting in a critical window of opportunity for instructing the immune system. This review highlights recent studies investigating the role of the microbiome in susceptibility or development of allergic diseases with a focus on animal models that provide insight into the mechanisms and pathways involved. Identification of a causal link between reduced microbial diversity or altered microbial composition and increased susceptibility to immune-mediated diseases will hopefully pave the way for better preventive therapies. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecornmons.org/licenses/by-nc-nd/4.0/).
机译：在过去的几十年中，过敏性疾病的增加与肠道菌群的组成和多样性的变化有关。微生物衍生的信号对于指导正在发育的免疫系统至关重要，相反，免疫调节会影响微生物群。在免疫系统仍在发育的早期阶段，微生物群组成中的扰动可能尤其重要，从而导致了指导免疫系统的关键机会。这篇综述重点介绍了最近的研究，该研究调查了微生物组在过敏性疾病的易感性或发展中的作用，重点是动物模型，该模型提供了对涉及的机制和途径的洞察力。鉴定减少的微生物多样性或改变的微生物组成与对免疫介导的疾病的敏感性增加之间的因果关系，有望为更好的预防性治疗铺平道路。 （C）2015作者。由Elsevier Inc.发行。这是CC BY-NC-ND许可下的开放获取文章（http://creativecornmons.org/licenses/by-nc-nd/4.0/）。

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