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首页> 外文期刊>Journal of refractive surgery >Very high-frequency ultrasound analysis of non-contact holmium laser thermal keratoplasty treatment spots.
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Very high-frequency ultrasound analysis of non-contact holmium laser thermal keratoplasty treatment spots.

机译：非接触式laser激光热角膜移植治疗部位的超高频超声分析。

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PURPOSE: To objectively measure the corneal treatment spots in vivo using very high-frequency ultrasound (VHFU) after non-contact laser thermal keratoplasty (LTK) to better understand the variability and regression of refractive outcomes. METHODS: In an institutional setting, VHFU was performed on 128 spots (8 eyes of 4 patients) using an immersion scanning technique 1 to 2 years after LTK with a single element focused transducer (50 MHz arc scanning ultrasound). Biometric techniques were used to evaluate the treatment spot depth, corresponding corneal thickness, and spot profile between patients, eyes (left/right), and by location on the cornea. The identical technique was used in a rabbit immediately after LTK to compare ultrasound versus histologic findings. RESULTS: The mean treatment spot penetration depth ranged between 0.373 and 0.533 mm, representing 64% to 78% of the corneal thickness compared to previous reports of 80% to 90%. Treatment spot depth, the corresponding corneal thickness, and percentage of overall cornea penetrated differed significantly across patients. Treatment spot depth was not significantly related to the level of applied laser energy (230 to 258 mJ) (0.082 Pearson sign). Spot profiles were not uniformly cone-shaped; W- and wedge-shaped were also identified. Ultrasound findings in the rabbit were similar to histology results and confirmed evidence of epithelial remodeling. CONCLUSIONS: Very high-frequency ultrasound of 128 treatment spots after non-contact LTK demonstrates epithelial remodeling and inconsistencies in penetration depth and profile.
机译：目的：在非接触式激光热角膜成形术（LTK）后使用超高频超声（VHFU）客观地测量体内角膜治疗点，以更好地了解屈光结果的变异性和回归性。方法：在机构环境中，在LTK术后1到2年使用单元素聚焦换能器（50 MHz弧形扫描超声），使用浸入式扫描技术对128个点（4例患者的8眼）进行VHFU。使用生物识别技术评估患者，眼睛（左/右）以及在角膜上的位置之间的治疗斑点深度，相应的角膜厚度以及斑点轮廓。 LTK后立即在兔子中使用相同的技术比较超声与组织学结果。结果：平均治疗斑穿透深度在0.373至0.533 mm之间，占角膜厚度的64％至78％，而先前的报道为80％至90％。不同患者的治疗斑深度，相应的角膜厚度和总的角膜百分比均存在显着差异。治疗光斑深度与所施加的激光能量水平（230至258 mJ）（0.082皮尔逊征）没有显着相关。光斑轮廓不是均匀的圆锥形。还可以识别出W形和楔形。兔的超声发现与组织学结果相似，并证实了上皮重塑的证据。结论：非接触式LTK术后128个治疗点的超高频超声显示上皮重塑以及穿透深度和轮廓不一致。

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