Synthesis and photodynamic activities of novel water soluble purpurin-18-N-methyl-D-glucamine photosensitizer and its gold nanoparticles conjugate

Lkhagvadulam B.; Kim J.H.; Yoon I.; Shim Y.K.

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Synthesis and photodynamic activities of novel water soluble purpurin-18-N-methyl-D-glucamine photosensitizer and its gold nanoparticles conjugate

机译：新型水溶性紫嘌呤-18-N-甲基-D-葡糖胺光敏剂及其金纳米粒子的合成及光动力活性

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A new type of water soluble ionic photosensitizer (PS), purpurin-18-N-methyl-D-glucamine (Pu-18-NMGA) has been synthesized and it was conjugated into gold nanoparticles (GNPs) stabilized by the PS without adding any particular reducing agents and surfactants. In vitro anticancer efficacy of the PS and its PSGNPs conjugate against A549 lung cancer cell lines was evaluated. The PSGNPs conjugate based on water-soluble Pu-18-NMGA afforded good PDT efficacy which was three times greater than that of the water-soluble PS.

机译：合成了一种新型的水溶性离子型光敏剂（purpurinin-18-N-methyl-D-glucamine）（Pu-18-NMGA），并将其偶联到由PS稳定的金纳米颗粒（GNP）中，而无需添加任何特别是还原剂和表面活性剂。评估了PS及其PSGNPs缀合物对A549肺癌细胞系的体外抗癌功效。基于水溶性Pu-18-NMGA的PSGNPs共轭物具有良好的PDT功效，是水溶性PS的三倍。

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《Journal of porphyrins and phthalocyanines》 |2012年第4期|共10页
作者
Lkhagvadulam B.; Kim J.H.; Yoon I.; Shim Y.K.;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
gold nanoparticles (GNPs) conjugate; N-methyl-D-glucamine (NMGA); photodynamic therapy (PDT); purpurin-18; water soluble photosensitizers;

机译：金纳米颗粒（GNPs）共轭物;N-甲基-D-葡萄糖胺（NMGA）;光动力疗法（PDT）;紫嘌呤18;水溶性光敏剂;

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1. Synthesis and photodynamic activities of novel water soluble purpurin-18-N-methyl-D-glucamine photosensitizer and its gold nanoparticles conjugate [J] . Lkhagvadulam B., Kim J.H., Yoon I., Journal of porphyrins and phthalocyanines . 2012,第4期

机译：新型水溶性紫嘌呤-18-N-甲基-D-葡糖胺光敏剂及其金纳米粒子的合成及光动力活性
2. Size-Dependent Photodynamic Activity of Gold Nanoparticles Conjugate of Water Soluble Purpurin-18-N-Methyl-D-Glucamine [J] . Byambajav Lkhagvadulam, Jung Hwa Kim, II Yoon, BioMed research international . 2013,第Pta3期

机译：金纳米颗粒缀合物的尺寸依赖性光动力学活性水溶性紫癜-18-N-甲基-D-葡聚糖的缀合物
3. Size-Dependent Photodynamic Activity of Gold Nanoparticles Conjugate of Water Soluble Purpurin-18-N-Methyl-D-Glucamine [J] . ByambajavLkhagvadulam, Jung HwaKim, IlYoon, BioMed research international . 2013,第2期

机译：金纳米粒子的尺寸依赖性光动力学活性与水溶性紫嘌呤-18-N-甲基-D-葡萄糖胺结合
4. Facile Green Synthesis and Characterization of Water Soluble Superparamagnetic Iron Oxide-Gold Porphyrin Conjugate for Improved Photodynamic Therapy [C] . Olayemi J. Fakayode, Sandile P. Songca, Oluwatobi S. Oluwafemi TMS annual meeting exhibition . 2017

机译：水溶性超顺磁性氧化铁-金卟啉偶联物的简易绿色合成和表征，用于改进光动力疗法
5. Synthesis of aptamer-porphyrin conjugate for photodynamic therapy & synthesis and stability of mixed thiol/lipid coated gold nanoparticles. [D] . Sitaula, Sarita. 2009

机译：用于光动力疗法的适体-卟啉偶联物的合成以及硫醇/脂质混合包被的金纳米粒子的合成和稳定性。
6. Size-Dependent Photodynamic Activity of Gold Nanoparticles Conjugate of Water Soluble Purpurin-18-N-Methyl-D-Glucamine [O] . Byambajav Lkhagvadulam, Jung Hwa Kim, Il Yoon, 2006

机译：金纳米颗粒的尺寸依赖性光动力学活性与水溶性紫嘌呤-18-N-甲基-D-葡萄糖胺结合
7. Size-Dependent Photodynamic Activity of Gold Nanoparticles Conjugate of Water Soluble Purpurin-18-N-Methyl-D-Glucamine [O] . Byambajav Lkhagvadulam, Jung Hwa Kim, Il Yoon, 2013

机译：金纳米颗粒缀合物的尺寸依赖性光动力学活性水溶性紫癜-18-N-甲基-D-葡聚糖的缀合物
8. One-Phase Synthesis of Water-Soluble Gold Nanoparticles with Control over Size and Surface Functionalities [R] . Oh, E., Susumu, K., Goswami, R., 2010

机译：水溶性金纳米粒子的单相合成，控制尺寸和表面功能

Synthesis and photodynamic activities of novel water soluble purpurin-18-N-methyl-D-glucamine photosensitizer and its gold nanoparticles conjugate

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