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首页> 外文期刊>Journal of refractive surgery >Intralase femtosecond laser vs mechanical microkeratomes in LASIK for myopia: A systematic review and meta-analysis
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Intralase femtosecond laser vs mechanical microkeratomes in LASIK for myopia: A systematic review and meta-analysis

机译：飞秒激光Intralase飞秒激光与机械微角膜刀在近视中的应用：系统评价和荟萃分析

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PURPOSE: To evaluate the safety, efficacy, and predictability of IntraLase (Abbott Medical Optics) femtosecond laser-assisted compared to microkeratome-assisted myopic LASIK. METHODS: A comprehensive literature search of Cochrane Library, PubMed, and EMBASE was conducted to identify relevant trials comparing LASIK with IntraLase femtosecond laser to LASIK with microkeratomes for the correction of myopia. Meta-analyses were performed on the primary outcomes (loss of ≥2 lines of corrected distance visual acuity [CDVA], uncorrected distance visual acuity [UDVA] 20/20 or better, manifest refraction spherical equivalent [MRSE] within ±0.50 diopters [D], final refractive SE, and astigmatism), and secondary outcomes (flap thickness predictability, changes in higher order aberrations [HOAs], and complications). RESULTS: Fifteen articles describing a total of 3679 eyes were identified. No significant differences were identified between the two groups in regards to a loss of ≥2 lines of CDVA (P=.44), patients achieving UDVA 20/20 or better (P=.24), final UDVA (P=.12), final mean refractive SE (P=.74), final astigmatism (P=.27), or changes in HOAs. The IntraLase group had more patients who were within ±0.50 D of target refraction (P=.05) compared to the microkeratome group, and flap thickness was more predictable in the IntraLase group (P<.0001). The microkeratome group had more epithelial defects (P=.04), whereas the IntraLase group had more cases of diffuse lamellar keratitis (P=.01). CONCLUSIONS: According to the available data, LASIK with the IntraLase femtosecond laser offers no significant benefits over LASIK with microkeratomes in regards to safety and efficacy, but has potential advantages in predictability.
机译：目的：与微角膜刀辅助近视LASIK相比，评估IntraLase（Abbott Medical Optics）飞秒激光辅助的安全性，有效性和可预测性。方法：对Cochrane Library，PubMed和EMBASE进行了全面的文献检索，以鉴定将LASIK与IntraLase飞秒激光与LASIK与微角膜刀进行比较以矫正近视的相关试验。对主要结局进行荟萃分析（≥2行校正的远视力[CDVA]，未校正的远视力[UDVA] 20/20或更高，在±0.50屈光度[D]内表现出屈光球当量[MRSE]） ]，最终屈光SE和散光）以及次要结局（皮瓣厚度可预测性，高阶像差[HOA]的变化和并发症）。结果：确定了15篇文章，描述了总共3679只眼睛。两组之间在CDVA丢失≥2行（P = .44），达到UDVA 20/20或更高（P = .24），最终UDVA（P = .12）方面没有发现显着差异。 ，最终平均屈光SE（P = .74），最终散光（P = .27）或HOA变化。与微型角膜刀组相比，IntraLase组有更多患者位于目标屈光度的±0.50 D以内（P = .05），IntraLase组的皮瓣厚度更可预测（P <.0001）。微型角膜刀组有更多的上皮缺损（P = .04），而IntraLase组则有更多的弥漫性片状角膜炎病例（P = .01）。结论：根据可获得的数据，就内在激光飞秒激光而言，LASIK在安全性和有效性方面不比具有微型角膜刀的LASIK优势大，但在可预测性方面具有潜在优势。

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