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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction.
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Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction.

机译：Abatacept调节人树突状细胞刺激的T细胞增殖和效应器功能，而与IDO诱导无关。

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摘要

Abatacept, the first in a new class of agents for RA, modulates CD28-mediated T-cell costimulation. Abatacept was evaluated for its ability to regulate human T-cell proliferation and cytokine production initiated by dendritic cells. Abatacept reduced T-cell proliferation by >95% at concentrations between 0.3 and 3 microg/ml. The effect of abatacept on T-cell proliferation was not through induction of IDO activity, as no increase in IDO mRNA or kynurenine was observed and 1-methyl-D-tryptophan did not reverse the inhibition. In addition to the effect of abatacept on proliferation, T-cell cytokines, IL-2, TNFalpha and IFNgamma were also reduced. Abatacept also inhibited proliferation and cytokine production in a T-cell memory response. These data demonstrate that abatacept, independent of IDO activity, attenuates both naive and memory T-cell proliferation and effector function. Taken together, these data aid our understanding of the mechanism for efficacy of abatacept in patients with autoimmune disease.
机译：Abatacept是一类新型的RA药物中的第一个，可调节CD28介导的T细胞共刺激。评价了Abatacept调节人T细胞增殖和由树突状细胞引发的细胞因子产生的能力。当浓度在0.3和3微克/毫升之间时，阿巴西普可使T细胞增殖减少> 95％。阿巴西普对T细胞增殖的影响不是通过诱导IDO活性来实现的，因为未观察到IDO mRNA或犬尿氨酸的增加，并且1-甲基-D-色氨酸未逆转抑制作用。除了阿巴西普对增殖的影响之外，还降低了T细胞细胞因子，IL-2，TNFα和IFNγ。 Abatacept还抑制T细胞记忆反应中的增殖和细胞因子产生。这些数据表明，阿巴西普不依赖于IDO活性，可减弱幼稚和记忆性T细胞增殖以及效应子功能。综上所述，这些数据有助于我们了解阿巴西普在自身免疫性疾病患者中的疗效机制。

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