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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >B cells require 'nurturing' by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus.
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B cells require 'nurturing' by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus.

机译：为了在系统性红斑狼疮的慢性移植物抗宿主模型中做出反应，B细胞在发育过程中需要CD4 T细胞的“培育”。

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摘要

The murine chronic GVH (cGVH) model of SLE is induced by allo-recognition of foreign major histocompatibility complex (MHC) class II determinants. Previous studies have shown that syngeneic CD4(+) T cells are needed during B cell development in order to induce cGVH response in CD4KO mice. Our present studies show that B cells require "nurturing" by CD4 T cells through much of their ontogeny in order to respond to allo-signaling and become autoreactive. The nurturing process does not require antigen-specific cognate interactions between CD4 T cells and B cells. It is mediated by IL-4, but not IL-10, IL-6 and IFN-gamma. The CD4 T cell nurturing may be supplanted by large doses of IL-4 and/or by agonistic anti-CD40 mAb. Understanding the mechanism of this nurturing host defense in general.
机译：SLE的小鼠慢性GVH（cGVH）模型是通过对外来主要组织相容性复合物（MHC）II类决定簇的同种异体识别而诱导的。先前的研究表明，在B细胞发育过程中需要同系的CD4（+）T细胞才能在CD4KO小鼠中诱导cGVH反应。我们目前的研究表明，B细胞需要CD4 T细胞通过其大部分个体发育来“培育”，以对同种信号作出反应并发生自身反应。培养过程不需要CD4 T细胞和B细胞之间的抗原特异性同源相互作用。它是由IL-4介导的，但不是由IL-10，IL-6和IFN-γ介导的。可以通过大剂量的IL-4和/或激动性抗CD40 mAb替代CD4 T细胞的培养。大致了解这种增强主机防御的机制。

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