CD4+ T-cells lymphocytosis and reduction of neutrophils during treatment with adalimumab: Challenge and dechallenge study.

Ursini F; Naty S; Bruno C; Calabria M; Spagnolo F; Grembiale RD

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CD4+ T-cells lymphocytosis and reduction of neutrophils during treatment with adalimumab: Challenge and dechallenge study.

机译：阿达木单抗治疗期间CD4 + T细胞淋巴细胞增多和嗜中性白细胞减少：挑战和挑战研究。

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In this letter we document a case of CD4+ cells lympho-cytosis with reduction in blood neutrophils during treatment with adalimumab including dechallenge and rechallenge. TNF-a targeting agents (infliximab, adalimumab, etanercept) represent the first-line biologic therapy for the treatment of different rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis [1], Severe hematologic complications are a rare adverse drug reaction to anti-TNF-a treatment. Clinical trial showed cases of aplastic anaemia [2] and pancytopenia potentially related to the administration TNF-a blocking agents.

机译：在这封信中，我们记录了一例CD4 +细胞淋巴细胞增多症，在使用阿达木单抗治疗期间（包括去挑战和再挑战），血液中性粒细胞减少。 TNF-a靶向剂（英夫利昔单抗，阿达木单抗，依那西普）是治疗不同风湿性疾病（如类风湿性关节炎，银屑病关节炎和强直性脊柱炎[1]）的一线生物疗法，严重的血液学并发症是罕见的药物不良反应进行抗TNF-α治疗。临床试验显示再生障碍性贫血[2]和全血细胞减少症的病例可能与TNF-α阻断剂的给药有关。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2010年第3期|共2页
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Ursini F; Naty S; Bruno C; Calabria M; Spagnolo F; Grembiale RD;
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1. CD4+ T-cells lymphocytosis and reduction of neutrophils during treatment with adalimumab: Challenge and dechallenge study. [J] . Ursini F, Naty S, Bruno C, Clinical immunology: The official journal of the Clinical Immunology Society . 2010,第3期

机译：阿达木单抗治疗期间CD4 + T细胞淋巴细胞增多和嗜中性白细胞减少：挑战和挑战研究。
2. T-cell large granular lymphocytic (LGL) leukemia consists of CD4+/CD8dim and CD4-/CD8+ LGL populations in association with immune thrombocytopenia, autoimmune neutropenia, and monoclonal B-cell lymphocytosis [J] . Naoya Kuwahara, Taiichi Kodaka, Yuriko Zushi, Journal of clinical and experimental hematopathology : . 2019,第4期

机译：T细胞大颗粒淋巴细胞（LGL）白血病由CD4 + / CD8dim和CD4- / CD8 + LGL人群组成，并伴有免疫性血小板减少，自身免疫性中性粒细胞减少和单克隆B细胞淋巴细胞增多
3. Value of s-ACE, BAL lymphocytosis, and CD4 +/CD8+ and CD103+CD4+/CD4+ T-cell ratios in diagnosis of sarcoidosis [J] . HyldgaardC., KaaeS., RiddervoldM., The European respiratory journal : . 2012,第4期

机译：s-ACE，BAL淋巴细胞增多以及CD4 + / CD8 +和CD103 + CD4 + / CD4 + T细胞比率在结节病诊断中的价值
4. Acceptance and Commitment Therapy (ACT) treatment groups targeting the reduction of problematic anger-related behaviors and psychological inflexibility in incarcerated men: A pilot study. [D] . Plambeck, Katherine L. 2015

机译：接受和承诺疗法（ACT）治疗组的目标是减少被监禁的男性中与愤怒有关的行为和心理上的僵硬，这是一项先导研究。
5. The Factors Related to CD4+ T-Cell Recovery and Viral Suppression in Patients Who Have Low CD4+ T Cell Counts at the Initiation of HAART: A Retrospective Study of the National HIV Treatment Sub-Database of Zhejiang Province China 2014 [O] . Lin He, Xiaohong Pan, Zhihui Dou, -1

机译：HAART启动时CD4 + T细胞计数低的患者CD4 + T细胞恢复和病毒抑制的相关因素：中国浙江省国家艾滋病治疗子数据库的回顾性研究2014年
6. Monoclonal TCR-Vβ13.1+/CD4+/NKa +/CD8-/+dim T-LGL lymphocytosis: Evidence for an antigen-driven chronic T-cell stimulation origin [O] . Garrido Pilar, Bárcena Paloma, Balanzategui Ana, 2012

机译：单克隆TCR-Vβ13.1+ / CD4 + / NKa + / CD8-/ + dim T-LGL淋巴细胞增多：抗原驱动的慢性T细胞刺激起源的证据
7. Paving Asphalt;Reduction of Oxidative Hardening of Asphalts by Treatment with Hydrated Lime-A Mechanistic Study. [R] . plancher, h. green, e. l. 1978

机译：铺路沥青;用水合石灰处理降低沥青的氧化硬化 - 机理研究。

CD4+ T-cells lymphocytosis and reduction of neutrophils during treatment with adalimumab: Challenge and dechallenge study.

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