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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Antibody and cytokine responses to house dust mite allergens and Toxoplasma gondii antigens in atopic and non-atopic Brazilian subjects.
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Antibody and cytokine responses to house dust mite allergens and Toxoplasma gondii antigens in atopic and non-atopic Brazilian subjects.

机译：特应性和非特应性巴西受试者对室内尘螨过敏原和弓形虫抗原的抗体和细胞因子反应。

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According to hygiene hypothesis, a lower exposure to infection is associated with increased prevalence of allergic diseases. This study aimed to investigate the association between atopy and Toxoplasma gondii (Tg) infection by analyzing the antibody and cytokine responses to house dust mite allergens and T. gondii antigens in Brazilian subjects. A total of 275 individuals were assessed and divided into atopics (n=129) and non-atopics (n=146) based on markers of allergy (positive skin prick test and ELISA-IgE to mite allergens) or Tg-seropositive (n=116) and Tg-seronegative (n=159) groups according to infection markers (positive ELISA-IgG to T. gondii). Tg-seropositive individuals presented lower allergenic sensitization (37%) to mite allergens than Tg-seronegative subjects (54%). A significant association was found between atopy and negative serology to T. gondii (OR: 2.0; 95% CI: 1.23-3.26; P<0.05). Proliferative responses and cytokine production after antigenic stimulation showed predominant synthesis of Th1-cytokines as IFN-gamma in Tg-seropositive patients, whether atopics or non-atopics. Conversely, Th2-cytokines as IL-5 prevailed in atopics compared to non-atopics, regardless the seropositivity to T. gondii. Levels of IL-10, IL-13, IL-17, and TGF-beta were not able to discriminate the groups. Hence, a negative association between atopy and infection by T. gondii was demonstrated for the first time in Brazilian subjects, focusing on the antibody and cytokine responses and indicating that the immunomodulation induced by the parasite may play a protective role in the development of allergic diseases.
机译：根据卫生学假设，较低的感染暴露与过敏性疾病的患病率增加有关。本研究旨在通过分析巴西受试者对屋尘螨变应原和弓形虫抗原的抗体和细胞因子应答，来研究特应性病毒与弓形虫（Tg）感染之间的关联。根据过敏反应的标记（阳性皮肤点刺试验和针对螨过敏原的ELISA-IgE）或Tg血清阳性（n =），共评估了275名个体，并将其分为特应性（n = 129）和非特应性（n = 146）。 116）和Tg血清阴性（n = 159）组根据感染标志物（弓形虫的ELISA-IgG阳性）。 Tg血清反应阳性的个体对螨过敏原的过敏原敏感性较低（37％），而Tg血清阴性的个体（54％）较低。发现特异性和弓形虫阴性血清学之间存在显着相关性（OR：2.0; 95％CI：1.23-3.26; P <0.05）。抗原刺激后的增殖反应和细胞因子产生显示，Tg血清反应阳性的患者，无论是特应性过敏还是非特应性过敏反应，Th1细胞因子主要以IFN-γ的形式合成。相反，与非特应性相比，Th2细胞因子IL-5占主导地位，而不管弓形虫的血清反应阳性。 IL-10，IL-13，IL-17和TGF-β的水平无法区分这些组。因此，在巴西受试者中首次证明了特应性病与弓形虫感染之间的负相关，重点在于抗体和细胞因子的应答，并表明由寄生虫诱导的免疫调节可能在过敏性疾病的发展中起保护作用。 。

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