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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease.
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Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease.

机译：用IL-15分化的单核细胞支持对小麦醇溶蛋白的Th17和Th1反应：对乳糜泻的影响。

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摘要

Interleukin (IL)-15 contributes to the immunopathogenesis of Celiac disease (CD). However, it is not clear how IL-15 affects APC that shape adaptive immune responses to the dietary antigen, gliadin. Using PBMC from healthy individuals, we show that monocytes differentiated with IL-15 (IL15-DC) produced IL-1beta, IL-6, IL-15, IL-23, TNFalpha and CCL20 in response to pepsin-trypsin digested gliadin (PTG) and activated contact-dependent Th17 and Th1 responses from autologous CD4(+) T cells. Lower concentrations of IL-15 augmented IFNgamma responses to PTG in PBMC from CD patients compared to controls. Thus, IL-15 supports Th17 and Th1 responses to a dietary antigen that is normally well-tolerated in healthy individuals by generating IL15-DC. These potentially pathogenic immune responses may result in CD patients and not healthy individuals as a consequence of IL-15 hypersensitivity. Therefore, genetic and/or environmental factors that control IL-15 expression and responsiveness in the intestine likely participate in the pathogenesis of CD.
机译：白介素（IL）-15有助于乳糜泻（CD）的免疫发病机理。但是，尚不清楚IL-15如何影响APC，从而形成对膳食抗原麦醇溶蛋白的适应性免疫反应。使用来自健康个体的PBMC，我们显示与IL-15（IL15-DC）分化的单核细胞响应胃蛋白酶-胰蛋白酶消化的麦醇溶蛋白（PTG）产生IL-1beta，IL-6，IL-15，IL-23，TNFalpha和CCL20 ）和自体CD4（+）T细胞激活的依赖接触的Th17和Th1反应。与对照组相比，CD患者PBMC中较低浓度的IL-15增强了对PTG的IFNγ反应。因此，IL-15通过产生IL15-DC来支持Th17和Th1对通常在健康个体中具有良好耐受性的饮食抗原的反应。这些潜在的致病性免疫反应可能会导致CD患者，而不是健康的个体，这是IL-15超敏反应的结果。因此，控制肠道中IL-15表达和反应性的遗传和/或环境因素可能参与CD的发病机制。

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