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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Down-regulation of adhesion molecules and matrix metalloproteinases by ZK 156979 in inflammatory bowel diseases.
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Down-regulation of adhesion molecules and matrix metalloproteinases by ZK 156979 in inflammatory bowel diseases.

机译：ZK 156979在炎症性肠病中下调粘附分子和基质金属蛋白酶。

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摘要

Intracellular adhesion molecules and matrix metalloproteinases (MMPs) are up-regulated in intestinal mucosa of patients with inflammatory bowel diseases (IBD), i.e. ulcerative colitis (UC) or Crohn's disease (CD). Our aim was to verify whether the vitamin D analogue ZK 156979 (ZK) down-regulates adhesion molecules, and decreases MMPs production by PBMC of IBD patients. ICAM-1 and LFA-1 levels increase, when PBMC were incubated with PHA or LPS or TNF-alpha, and decrease when these substances were used in combination with ZK. MMPs activity increases incubating the cells with PHA or LPS or TNF-alpha. MMP-9 decreases when ZK was used in association, while MMP-2 decreases only when ZK was used in combination with anti-TNF-alpha. Our results suggest that the down-regulation of ICAM-1 and LFA-1 on PBMC and the inhibition of MMP-9 activity by ZK could provide a potential role of this low calcemic vitamin D derivative in future strategies in IBD therapy.
机译：在患有炎症性肠病（IBD）（即溃疡性结肠炎（UC）或克罗恩病（CD））的患者的肠粘膜中，细胞内粘附分子和基质金属蛋白酶（MMP）上调。我们的目的是验证维生素D类似物ZK 156979（ZK）是否下调IBD患者的PBMC的黏附分子并降低其MMP产生。当PBMC与PHA或LPS或TNF-α一起孵育时，ICAM-1和LFA-1的水平升高，而当这些物质与ZK组合使用时，ICAM-1和LFA-1的水平则降低。在将细胞与PHA或LPS或TNF-α一起孵育时，MMP活性增加。当ZK联合使用时，MMP-9降低，而MMP-2仅在ZK与抗TNF-α组合使用时降低。我们的结果表明ZK对ICAM-1和LFA-1的下调以及ZK对MMP-9活性的抑制作用可能在未来IBD治疗策略中提供这种低钙血症性维生素D衍生物的潜在作用。

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