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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.
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Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.

机译：成功的离体扩增后，来自免疫介导疾病患者的调节性T细胞的抑制功能增强。

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Recent studies and our current data demonstrated the deficits in the numbers and/or functions of the CD4(+)CD25(+)Foxp3(+) Treg cells in the patients with autoimmune diseases, indicating that restoration of Treg cells in these patients could be a potential therapeutic approach. Here, we demonstrated that CD4(+)CD25(+)Foxp3(+) Treg cells can be purified, activated and expanded from peripheral blood of patients with immune-mediated diseases, to a similar degree to those from healthy donors. Within 3weeks, Treg cells from most patients could be expanded ex vivo 100-2000 fold and maintained their phenotypic characteristics. Furthermore, ex vivo expanded Treg cells displayed potent and enhanced in vitro suppressive activities inhibiting T effector cell proliferation compared to Treg cells freshly purified from the same patients. The expanded Treg cells with enhanced biological function may provide an opportunity to restore the proper balance of immunity and tolerance, suggesting the potential of using Treg cell therapy for treatment of immune-mediated diseases.
机译：最近的研究和我们目前的数据表明，患有自身免疫性疾病的患者的CD4（+）CD25（+）Foxp3（+）Treg细胞数量和/或功能存在缺陷，这表明这些患者中Treg细胞的恢复可能是一种潜在的治疗方法。在这里，我们证明了CD4（+）CD25（+）Foxp3（+）Treg细胞可以从免疫介导疾病患者的外周血中纯化，激活和扩增，其程度与健康供体的相似。在3周内，大多数患者的Treg细胞可以离体扩增100-2000倍，并保持其表型特征。此外，与从同一患者新鲜纯化的Treg细胞相比，离体扩增的Treg细胞显示出强大的和增强的体外抑制活性，抑制了T效应细胞的增殖。具有增强的生物学功能的扩增的Treg细胞可以提供恢复免疫和耐受性的适当平衡的机会，表明使用Treg细胞疗法来治疗免疫介导的疾病的潜力。

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