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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses.
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Glycyrrhizin improves the resistance of MAIDS mice to opportunistic infection of Candida albicans through the modulation of MAIDS-associated type 2 T cell responses.

机译：甘草甜素通过调节与MAIDS相关的2型T细胞应答来提高MAIDS小鼠对白色念珠菌的机会性感染的抵抗力。

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摘要

Compared with normal mice, MAIDS mice (mice infected with LP-BM5 murine leukemia virus) exhibited an increase up to 100 times greater in susceptibility to infection with Candida albicans. The impaired resistance of MAIDS mice to the infection was recovered to levels observed in normal mice by the administration of glycyrrhizin (GR), an active component of licorice roots. MAIDS mice inoculated with CD4(+) T cells from GR-treated mice were also resistant to C. albicans infection. Normal mice inoculated with CD4(+) T helper type 2 cells (Th2 cells) from MAIDS mice were susceptible to C. albicans infection at the same levels shown in MAIDS mice. The susceptibility of normal mice inoculated with type 2 T cells was reversible by (i) administration of GR and (ii) inoculation of CD4(+) T cells from GR-treated mice and injection of a mixture of mAbs targeted against type 2 cytokines (IL-4 and IL-10). Type 2 cytokines were not detected in sera of MAIDS mice inoculated with CD4(+) T cells from GR-treated mice, while they were present in sera of MAIDS mice treated with saline. These results suggest that, by inducing CD4(+) T cells which suppress type 2 cytokine production by MAIDS-associated Th2 cells, GR improves the resistance of MAIDS mice to C. albicans infection. Copyright 2000 Academic Press.
机译：与正常小鼠相比，MAIDS小鼠（感染了LP-BM5鼠白血病病毒的小鼠）对白色念珠菌感染的敏感性增加了多达100倍。通过施用甘草根的活性成分甘草甜素（GR），使MAIDS小鼠对感染的抵抗力受损恢复到正常小鼠中观察到的水平。接种GR治疗小鼠的CD4（+）T细胞的MAIDS小鼠也对白色念珠菌感染具有抗性。接种了来自MAIDS小鼠的CD4（+）T辅助2型细胞（Th2细胞）的正常小鼠容易感染白色念珠菌，其感染水平与MAIDS小鼠相同。通过（i）施用GR和（ii）接种GR治疗小鼠的CD4（+）T细胞并注射针对2型细胞因子的单克隆抗体混合物，可逆转接种2型T细胞的正常小鼠的易感性（ IL-4和IL-10）。在用GR治疗的小鼠接种CD4（+）T细胞的MAIDS小鼠血清中未检测到2型细胞因子，而在用盐水处理的MAIDS小鼠血清中存在2型细胞因子。这些结果表明，通过诱导抑制MAIDS相关Th2细胞产生2型细胞因子产生的CD4（+）T细胞，GR可以提高MAIDS小鼠对白色念珠菌感染的抵抗力。版权所有2000学术出版社。

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