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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Derivation of diabetes-resistant congenic lines from the nonobese diabetic mouse.
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Derivation of diabetes-resistant congenic lines from the nonobese diabetic mouse.

机译：从非肥胖型糖尿病小鼠衍生抗糖尿病的同基因系。

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摘要

Autoimmune diabetes is a polygenic disease process in man and rodents. To identify and characterize genes involved in the pathogenesis of diabetes in nonobese diabetic (NOD) mice, we initiated a repetitive backcross of diabetes-resistant C57L/J mice onto the NOD strain. This breeding scheme was based on the premise that selection for the trait of disease resistance among genetically mixed mice could be used to maintain transmission of nonpermissive alleles from the diabetes-resistant strain at critical diabetes susceptibility loci. Each of the three recombinant congenic mouse lines derived by this strategy retains a unique constellation of C57L/J-derived DNA segments. Consistent with the involvement of different genetic loci, the pancreatic histology of disease-resistant mice differs from that in NOD mice in a line-specific manner. Functional studies using these lines demonstrate that pathogenesis of autoimmune diabetes is a multistep process which can be blocked at a minimum of three critical, genetically determined points. Copyright 2000 Academic Press.
机译：自身免疫性糖尿病是人和啮齿动物的多基因疾病过程。为了鉴定和表征参与非肥胖糖尿病（NOD）小鼠糖尿病发病机理的基因，我们启动了将抗糖尿病C57L / J小鼠重复回交到NOD株上的方法。该育种方案是基于这样的前提，即在遗传混合小鼠中选择抗病性状可用于维持来自糖尿病抗性品系的非许可等位基因在关键糖尿病易感基因座的传播。通过这种策略衍生的三个重组同基因小鼠品系中的每一个都保留了C57L / J衍生DNA片段的独特构象。与不同基因位点的参与一致，抗病小鼠的胰腺组织学与NOD小鼠的胰腺组织学以线特异性方式不同。使用这些品系的功能研究表明，自身免疫性糖尿病的发病机制是一个多步骤过程，可以在至少三个关键的遗传确定的点被阻断。版权所有2000学术出版社。

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