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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >T lymphocyte abnormalities in juvenile systemic sclerosis patients
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T lymphocyte abnormalities in juvenile systemic sclerosis patients

机译：幼年系统性硬化症患者的T淋巴细胞异常

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摘要

Multi-center evaluations of pediatric patients with juvenile systemic sclerosis (jSSc) have suggested that the pathogenesis of jSSc may differ from that of systemic sclerosis (SSc) in adult patients. Therefore, we undertook to identify abnormalities in the T lymphocytes of jSSc patients and to determine if they differed from the abnormalities reported in the T lymphocytes of adult SSc patients. We identified decreases in the frequency of resting regulatory T lymphocytes and an increased frequency of CD45RA expressing effector memory (EMRA) CD4 T lymphocytes, which were characterized by an increased frequency of CCR7 protein expressing cells. Neither the increases in the EMRA subpopulation nor the increased CCR7 protein expression have been reported in adult SSc patients. The decrease in resting regulatory T lymphocytes in jSSc patients may permit the expansion of the disease initiating CD4 T lymphocytes present in the CCR7 expressing EMRA CD4 T lymphocyte subpopulation.
机译：小儿青少年系统性硬化症（jSSc）的多中心评估表明，成年患者jSSc的发病机制可能与系统性硬化症（SSc）有所不同。因此，我们致力于鉴定jSSc患者的T淋巴细胞异常，并确定它们是否与成人SSc患者的T淋巴细胞异常有所区别。我们发现静息调节性T淋巴细胞的频率减少，而CD45RA表达的效应记忆（EMRA）CD4 T淋巴细胞的频率增加，其特征是CCR7蛋白表达细胞的频率增加。在成年SSc患者中，既没有报告EMRA亚群的增加也没有报告CCR7蛋白表达的增加。 jSSc患者中静息调节性T淋巴细胞的减少可能会导致表达CRA7的表达EMRA CD4 T淋巴细胞亚群的疾病引发CD4 T淋巴细胞的扩大。

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