The role of miR-155 in regulatory T cells and rheumatoid arthritis

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The role of miR-155 in regulatory T cells and rheumatoid arthritis

机译：miR-155在调节性T细胞和类风湿关节炎中的作用

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Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.

机译：最近，在风湿性关节炎（RA）的环境中发现了多种micro（mi）RNA失控，但它们在该疾病的发病机理中的作用仍存在争议。同时，越来越多的证据表明RA中调节性T细胞（Tregs）的功能有缺陷。这篇综述讨论了有关RA中Tregs和细胞毒性T淋巴细胞抗原4的功能的相关研究，提供了miRNA在Treg稳态中的作用的最新数据，并着重于miR-155在Tregs中的作用。在最后的视角部分，我们讨论了治疗性miR-155调节对RA的潜在影响。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2013年第1期|共10页
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正文语种 eng
中图分类医学免疫学;
关键词
Cytotoxic T-Lymphocyte Antigen 4; MicroRNA; Regulatory T cells; Rheumatoid arthritis; Therapy;

机译：细胞毒性T淋巴细胞抗原4;MicroRNA;调节性T细胞;类风湿关节炎;治疗;

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1. The role of miR-155 in regulatory T cells and rheumatoid arthritis [J] . Clinical immunology: The official journal of the Clinical Immunology Society . 2013,第1期

机译：miR-155在调节性T细胞和类风湿关节炎中的作用
2. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications [J] . Alunno Alessia, Manetti Mirko, Caterbi Sara, Mediators of inflammation . 2015,第2期

机译：类风湿性关节炎的免疫调节改变：调节性T细胞和促炎TH17细胞的作用和治疗意义
3. Role of new population of peripheral CD11c(+)CD8(+) T cells and CD4(+)CD25(+) regulatory T cells during acute and remission stages in rheumatoid arthritis patients. [J] . Kao JK, Hsue YT, Lin CY Journal of microbiology, immunology, and infection: Wei mian yu gan ran za zhi . 2007,第5期

机译：类风湿关节炎患者急性和缓解阶段新的外周CD11c（+）CD8（+）T细胞和CD4（+）CD25（+）调节性T细胞的作用。
4. Expression of CD4+CD25+ T regulatory cells and Foxp3 in peripheral blood of patients with Rheumatoid Arthritis Patient [C] . Kexin Sun, Yan Li, Suhong Guo, International Conference on Applied Science, Engineering and Technology . 2013

机译：类风湿性关节炎患者外周血CD4 + CD25 + T调节细胞和FOXP3的表达
5. A soluble survival signal from CD14+ cells and its possible role in the pathogenesis of rheumatoid arthritis. [D] . Tang, Xiaolei. 2001

机译：来自CD14 +细胞的可溶性存活信号及其在类风湿性关节炎发病中的可能作用。
6. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications [O] . Alessia Alunno, Mirko Manetti, Sara Caterbi, 2015

机译：类风湿关节炎中的免疫调节改变：调节性T细胞和促炎性Th17细胞的作用和治疗意义
7. The role of dietary sodium intake on the modulation of T helper 17 cells and regulatory T cells in patients with rheumatoid arthritis and systemic lupus erythematosus [O] . Scrivo, Rossana, Massaro, Laura, Barbati, Cristiana, 2017

机译：饮食中钠的摄入对类风湿关节炎和系统性红斑狼疮患者辅助性T细胞17和调节性T细胞的调节作用
8. Differential Reactivity of Rheumatoid Synovial Cells and Serum Rheumatoid Factors to Human Immunoglobulin G Subclasses 1 and 3 and Their CH3 Domains in Rheumatoid Arthritis [R] . Robbins, D. L., Benisek, W. F., Benjamini, E., 1987

机译：类风湿关节炎细胞和血清类风湿因子对人免疫球蛋白G亚类1和3及其类风湿性关节炎CH3区的差异反应性

The role of miR-155 in regulatory T cells and rheumatoid arthritis

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