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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Accelerated vascular disease in systemic lupus erythematosus: Role of macrophage
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Accelerated vascular disease in systemic lupus erythematosus: Role of macrophage

机译：系统性红斑狼疮的加速血管疾病：巨噬细胞的作用

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摘要

Atherosclerosis is a chronic inflammatory condition that is considered a major cause of death worldwide. Striking phenomena of atherosclerosis associated with systemic lupus erythematosus (SLE) is its high incidence in young patients. Macrophages are heterogeneous cells that differentiate from hematopoietic progenitors and reside in different tissues to preserve tissue integrity. Macrophages scavenge modified lipids and play a major role in the development of atherosclerosis. When activated, macrophages secret inflammatory cytokines. This activation triggers apoptosis of cells in the vicinity of macrophages. As such, macrophages play a significant role in tissue remodeling including atherosclerotic plaque formation and rupture. In spite of studies carried on identifying the role of macrophages in atherosclerosis, this role has not been studied thoroughly in SLE-associated atherosclerosis. In this review, we address factors released by macrophages as well as extrinsic factors that may control macrophage behavior and their effect on accelerated development of atherosclerosis in SLE. (C) 2015 Elsevier Inc. All rights reserved.
机译：动脉粥样硬化是一种慢性炎性疾病，被认为是全球范围内的主要死亡原因。与系统性红斑狼疮（SLE）相关的动脉粥样硬化的惊人现象是其在年轻患者中的高发病率。巨噬细胞是异种细胞，可与造血祖细胞区分开并驻留在不同组织中以保持组织完整性。巨噬细胞清除修饰的脂质，并在动脉粥样硬化的发展中起主要作用。激活后，巨噬细胞会分泌炎性细胞因子。该激活触发巨噬细胞附近细胞的凋亡。因此，巨噬细胞在包括动脉粥样硬化斑块形成和破裂的组织重塑中起重要作用。尽管已经进行了有关识别巨噬细胞在动脉粥样硬化中的作用的研究，但是在与SLE相关的动脉粥样硬化中尚未充分研究这种作用。在这篇综述中，我们研究了巨噬细胞释放的因素以及可能控制巨噬细胞行为的外在因素，以及它们对SLE动脉粥样硬化加速发展的影响。 （C）2015 Elsevier Inc.保留所有权利。

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