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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED
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Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED

机译：对APECED中色氨酸羟化酶-1，芳香族L-氨基酸脱羧酶，AIE-75，villin和Paneth细胞的胃肠道免疫

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Gastrointestinal dysfunction is a disabling manifestation of APECED possibly related to an autoimmune intestinal aggression. We evaluated its features in a cohort of 31 Finnish patients. The most frequent manifestations were constipation (48%), diarrhea, dysphagia and retrosternal pain (45%). AADC and TPH-1 autoantibodies were detected in 51% and 45% of the patients, respectively. Forty-three percent displayed a T-cell response to AADC. One third of the patients also had AIE-75 (33%) and villin (29%)-specific autoantibodies while antibodies against brush borders and Paneth cells were detected in 29% and 20%, respectively. Intestinal IL-17 expression was absent/decreased in 77% of the cases. Duodenal CgA and serotonin expression was absent/decreased in 50% and 66% of the patients, respectively. Constipation correlated with lacking serotonin expression and AADC antibodies (p < 0.05). (C) 2015 Elsevier Inc. All rights reserved.
机译：胃肠功能障碍是APECED的致残表现，可能与自身免疫性肠侵袭有关。我们在31名芬兰患者中评估了其功能。最常见的表现是便秘（48％），腹泻，吞咽困难和胸骨后疼痛（45％）。在51％和45％的患者中分别检测到AADC和TPH-1自身抗体。 43％的人表现出对AADC的T细胞反应。三分之一的患者还具有AIE-75（33％）和villin（29％）特异的自身抗体，而分别检测到针对刷缘和Paneth细胞的抗体的分别为29％和20％。在77％的病例中肠IL-17表达缺失/降低。分别有50％和66％的患者十二指肠CgA和血清素表达缺失/降低。便秘与血清素表达和AADC抗体缺乏有关（p <0.05）。 （C）2015 Elsevier Inc.保留所有权利。

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