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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Immune-microbiota interactions in health and disease
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Immune-microbiota interactions in health and disease

机译：健康与疾病中的免疫微生物相互作用

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摘要

Recent studies have revealed that the intestinal microbiota plays an important role in host physiology and pathphysiology in health and disease. One of the major mechanisms by which the gut microbiota influences the host is through its interactions with and effects on the host immune system. In this review, we discuss the reciprocal interactions between the host immune system and the gut microbiota, with a particular focus on individual microbes that impact the host through dramatic and specific interactions with the adaptive immune system. We highlight the idea that the presence or absence of specific immunologically important members of the microbiota can determine disease susceptibility and propose that the identification and characterization of these bacteria in humans will eventually allow us to elucidate the role of microbiota composition in human disease. (C) 2015 Elsevier Inc. All rights reserved.
机译：最近的研究表明，肠道菌群在健康和疾病的宿主生理和病理生理中起着重要作用。肠道菌群影响宿主的主要机制之一是通过其与宿主免疫系统的相互作用和对宿主免疫系统的影响。在这篇综述中，我们讨论了宿主免疫系统和肠道菌群之间的相互相互作用，特别关注了通过与适应性免疫系统的戏剧性和特异性相互作用而影响宿主的单个微生物。我们着重指出微生物群的特定免疫学重要成员的存在与否可以确定疾病的易感性，并提出对这些细菌在人类中进行鉴定和表征最终将使我们能够阐明微生物群在人类疾病中的作用。 （C）2015 Elsevier Inc.保留所有权利。

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