Differential effects of genetic susceptibility factors in males and females with multiple sclerosis

SadovnickA.D.

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Differential effects of genetic susceptibility factors in males and females with multiple sclerosis

机译：遗传易感性因子在多发性硬化症男性和女性中的差异作用

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Multiple sclerosis (MS), a putative autoimmune disease, has a well documented female preponderance among patients. However, this is not the only sex effect observed in the disease. Unaffected mothers appear to be at a higher risk to transmit susceptibility (genetic, environmental or interactions thereof) compared to unaffected fathers. This maternal effect can range from intrauterine exposures to transmission of genotypes and epigenetics.

机译：多发性硬化症（MS）是一种公认的自身免疫性疾病，在患者中女性有很多优势。但是，这并不是在疾病中观察到的唯一性效应。与未受影响的父亲相比，未受影响的母亲似乎更易传播易感性（遗传，环境或其相互作用）。孕产妇的影响范围可能从宫内暴露到基因型和表观遗传学的传播。

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2013年第2期|共6页
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SadovnickA.D.;
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正文语种 eng
中图分类医学免疫学;
关键词
Gender; HLA DRB1; Maternal effect; Multiple sclerosis; Sex ratio; Susceptibility;

机译：性别;HLA DRB1;母亲效应;多发性硬化;性别比;易感性;

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1. Differential effects of genetic susceptibility factors in males and females with multiple sclerosis [J] . SadovnickA.D. Clinical immunology: The official journal of the Clinical Immunology Society . 2013,第2期

机译：遗传易感性因子在多发性硬化症男性和女性中的差异作用
2. The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females [J] . André L. S. Figueiredo, Carmen L. A. Paiva, Catielly F. Rocha, Arquivos de Neuro-Psiquiatria . 2015,第4期

机译：CIITA遗传多态性rs4774 * C与HLA-DRB1 * 15：01等位基因联合作为巴西女性多发性硬化的推定易感性因子
3. Americas Committee for Treatment and Research in Multiple Sclerosis Forum 2017: Environmental factors, genetics, and epigenetics in MS susceptibility and clinical course [J] . Segal Benjamin M., Cohen Jeffrey A., Antel Jack Multiple sclerosis: clinical and laboratory research . 2018,第1期

机译：2017年多发性硬化症论坛治疗和研究委员会：MS易感性和临床课程中的环境因素，遗传和表观遗传学
4. Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis [C] . GIUSI IRMA FORTE, PAOLO RAGONESE, GIUSEPPE SALEMI, International Association of Biomedical Gerontology International . 2006

机译：搜索与多发性硬化症易感相关的遗传因子
5. Genetic Mapping and Analysis of Disease Susceptibility in a Mouse Model of Multiple Sclerosis [D] . Bearoff, Frank M. 2017

机译：多发性硬化症小鼠模型的遗传图谱和疾病易感性分析
6. Differential Susceptibility of Male and Female Mice to Encephalomyocarditis Virus: Effects of Castration Adrenalectomy and the Administration of Sex Hormones [O] . Stanford B. Friedman, Lee J. Grota, Lowell A. Glasgow 1972

机译：雄性和雌性小鼠对脑心肌炎病毒的易感性：去势肾上腺切除术和性激素的管理的影响。
7. Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118-kb interval around interferon-gamma (IFNG) that is involved in male versus female differential susceptibility [O] . Goris An, Heggarty S, Marrosu M G, 2002

机译：多发性硬化症中染色体12q14-15的连锁不平衡分析：围绕男性和女性差异敏感性的干扰素-γ（IFNG）周围118-kb间隔的描绘

Differential effects of genetic susceptibility factors in males and females with multiple sclerosis

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