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首页> 外文期刊>Journal of Parasitology >Acetic Acid Induced Ulceration in Rats Is Not Affected by Infection with Hymenolepis diminuta
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Acetic Acid Induced Ulceration in Rats Is Not Affected by Infection with Hymenolepis diminuta

机译：乙酸诱导的大鼠溃疡不受小孢子虫感染的影响

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摘要

Analysis of rodent models of inflammatory bowel disease, airways hyper-reactivity, diabetes, and multiple sclerosis has shown that infection with helminth parasites can significantly reduce the severity of the disease. Here, we assessed whether rats infected with the tapeworm Hymenolepis diminuta were protected from gastric ulceration induced by the serosal application of acetic acid. All rats gavaged with infective cysticercoids harbored adult worms when assessed 6 wk later, and acetic acid evoked the expected gastric ulceration. However, infection with H. diminuta did not affect the degree of gastric ulceration at either 3 or 7 days post-acetic acid application, as gauged by ulcer area or histopathology. While the data do not dismiss the possibility that infection with other helminths could be anti-ulcerogenic, they illustrate that 'helminth therapy' for inflammatory disease is likely to be both disease- and helminth-specific.
机译：对炎症性肠病，气道反应过度，糖尿病和多发性硬化症的啮齿动物模型的分析表明，感染蠕虫寄生虫可以显着降低疾病的严重程度。在这里，我们评估了感染the虫Hymenolepis diminuta的大鼠是否被保护免于因浆膜施用乙酸引起的胃溃疡。 6周后评估时，所有感染了感染性类囊虫的大鼠均带有成虫，乙酸诱发了预期的胃溃疡。然而，如通过溃疡面积或组织病理学所衡量的那样，在应用乙酸后3或7天，感染小链球菌不会影响胃溃疡的程度。尽管数据不能排除其他蠕虫感染可能具有抗溃疡作用的可能性，但它们表明针对炎症性疾病的“蠕虫疗法”可能既针对疾病又针对蠕虫。

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