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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >TACI mutation p.Lys154Ter identified in Good Syndrome
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TACI mutation p.Lys154Ter identified in Good Syndrome

机译：在良好综合征中鉴定出TACI突变p.Lys154Ter

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The impact of vesicoureteral reflux (VUR) on renal allograft outcomes is debatable, with small cohort studies reporting controversial results. The objective of this retrospective study was to evaluate long-term clinical effects of early VUR in a large cohort of kidney transplant patients. Posttransplantation voiding cystourethrography was used to evaluate 646 consecutive kidney transplant recipients before discharge. The study endpoints included VUR grade, death-censored graft or patient survival, renal function, proteinuria and occurrence of urinary tract infections (UTIs). Of the 646 recipients, 263 (40.7%) were diagnosed with VUR. VUR grade II was most common (19.8%), followed by grades III (10.2%), I (7.9%) and IV (2.8%). VUR was less common in transplantations performed by experienced compared to inexperienced surgeons (36% vs. 48%; p = 0.004). VUR did not affect death-censored graft or patient survival and was not associated with proteinuria or occurrence of UTIs. Patients with VUR had a lower eGFR at 1 year after transplantation than did patients without VUR (60 vs. 52 mL/min/1.73 m2; p = 0.02), although this difference was not observed at 3 and 5 years after transplantation. We conclude that early VUR, a common finding among renal transplant patients, may not have a meaningful impact on long-term transplant outcomes. By examining the value of routine voiding cystourethrography in a large cohort of kidney transplant patients, the authors show that the early vesicoureteral reflux has no meaningful effect on death-censored graft survival or overall patient survival.
机译：膀胱输尿管反流（VUR）对同种异体肾结局的影响尚有争议，一些小型队列研究报告了有争议的结果。这项回顾性研究的目的是评估早期VUR在大量肾脏移植患者队列中的长期临床效果。移植后排尿膀胱尿道造影用于评估出院前的646位连续肾脏移植接受者。研究终点包括VUR级，以死亡检查的移植物或患者存活率，肾功能，蛋白尿和尿路感染（UTI）的发生。在646位接受者中，有263位（40.7％）被诊断出患有VUR。 VUR II级最常见（19.8％），其次是III级（10.2％），I级（7.9％）和IV级（2.8％）。与没有经验的外科医生相比，有经验的外科医生在VUR手术中较少见（36％比48％; p = 0.004）。 VUR不会影响以死亡检查的移植物或患者的存活率，并且与蛋白尿或尿路感染无关。 VUR患者在移植后1年的eGFR低于无VUR患者（60 vs. 52 mL / min / 1.73 m2; p = 0.02），尽管在移植后3年和5年未观察到这种差异。我们得出的结论是，早期VUR是肾移植患者中的常见发现，可能对长期移植结果没有有意义的影响。通过检查大型肾脏移植患者队列中常规排尿膀胱尿道造影的价值，作者表明早期膀胱输尿管反流对以死亡为前提的移植物存活或患者总体存活没有有意义的影响。

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