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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Follicular helper T cells may play an important role in the severity of primary Sj?gren's syndrome
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Follicular helper T cells may play an important role in the severity of primary Sj?gren's syndrome

机译：滤泡辅助性T细胞可能在原发性干燥综合征的严重性中起重要作用

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The aim of this study was to investigate the possible role of follicular helper T (TFH) cells in the pathogenesis of primary Sj?gren's syndrome (pSS) by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms. We enrolled 50 pSS patients and 16 healthy individuals in the study. Patients had elevated ratio of peripheral TFH cells, however, when dividing patients into two groups defined by the presence of extraglandular manifestations (EGMs), only patients with EGMs differed from controls significantly. Moreover, TFH cell percentages correlated positively with both activated T cell and Tr1 cell values. On the contrary, TFH cell percentages showed negative correlation with both IgM and IgG memory B cell proportions. Elevated TFH percentges were observed in the anti-SSA/SSB positive patients, and also in patients with higher IL-12, IL-21 levels and focus score values. Increased TFH cell proportions seem to have an important role in disease development.
机译：这项研究的目的是通过分析免疫功能细胞和血清标志物，特别是临床症状，来研究卵泡辅助性T（TFH）细胞在原发性干燥综合征（pSS）发病中的可能作用。我们招募了50名pSS患者和16名健康个体。患者外周血TFH细胞比例升高，但是，将患者分为存在腺外表现（EGM）的两组时，只有具有EGMs的患者与对照组明显不同。此外，TFH细胞百分比与激活的T细胞和Tr1细胞值均呈正相关。相反，TFH细胞百分数与IgM和IgG记忆B细胞百分数呈负相关。在抗SSA / SSB阳性患者以及IL-12，IL-21水平和焦点评分值较高的患者中观察到TFH百分比升高。 TFH细胞比例的增加似乎在疾病发展中具有重要作用。

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