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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line
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Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line

机译：抗原呈递细胞系中直接辐射诱导的免疫功能和分子信号传导变化的表征

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Radiation therapy is a widely used cancer treatment and pre-transplantation conditioning regimen that has the potential to influence anti-tumor and post-transplantation immune responses. Although conventionally fractionated radiation doses can suppress immune responses by depleting lymphocytes, single high doses of local tumor radiation can enhance immune responses. Using phospho-flow cytometry analysis of a human monocytic cell line, we identified novel radiation-induced changes in the phosphorylation state of NFκB family members known in other cell types to maintain and regulate immune function. These phosphorylation changes were p53 independent, but were strongly dependent upon ATM activation due to DNA damage. We found that radiation promotes the activation and APC functional maturation through phosphorylation of NFκB Essential Modulator (NEMO). Our results and the analytic methods are especially well suited to the study of functional changes in APC when radiation is used for immune modulation in clinical protocols.
机译：放射疗法是一种广泛使用的癌症治疗和移植前调理方案，具有影响抗肿瘤和移植后免疫反应的潜力。尽管传统上分次的放射剂量可以通过消耗淋巴细胞来抑制免疫反应，但是单次高剂量的局部肿瘤放射可以增强免疫反应。使用人类单核细胞系的磷酸流式细胞仪分析，我们确定了新的辐射诱导的其他细胞类型已知的NFκB家族成员磷酸化状态的变化，以维持和调节免疫功能。这些磷酸化变化与p53无关，但由于DNA损伤而强烈依赖于ATM激活。我们发现辐射通过NFκB基本调节剂（NEMO）的磷酸化促进激活和APC功能成熟。当放射线用于临床方案中的免疫调节时，我们的结果和分析方法特别适合研究APC的功能变化。

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