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首页> 外文期刊>Journal of Parasitology >Immunomodulation of the response to excretory/secretory antigens of Fasciola hepatica by anapsos in Balb/C mice and rat alveolar macrophages.
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Immunomodulation of the response to excretory/secretory antigens of Fasciola hepatica by anapsos in Balb/C mice and rat alveolar macrophages.

机译：在Balb / C小鼠和大鼠肺泡巨噬细胞中通过无反应对肝片Fasciola肝分泌/分泌抗原的应答进行免疫调节。

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摘要

It is known that excretory/secretory antigens of Fasciola hepatica (ESFh) trigger a Th2-like immune response. Anapsos (A) is an aqueous hydrosoluble extract obtained from the rhizomes of the fern Polypodium leucotomos that has shown immunomodulator effects in some parasitic infections and immunological disorders. In this work we assess the effect of Anapsos and ESFh and Quillaja saponaria extract (Qs) on BALB/c mice and rat alveolar macrophages. Anapsos modulates the response of mice immunized with ESFh, decreasing IgG antibodies in A+ESFh- and A+Qs+ESFh-treated mice and triggering high levels of gammaIFN in spleen cell culture in comparison with ESFh- and Qs + ESFh--treated groups. Moreover, Anapsos showed statistically significant inhibitory effects on the nitrite production by rat alveolar macrophages prestimulated with lipopolysaccharide (LPS) as well as ESFh antigen in comparison with macrophages stimulated only with LPS. The application of ESFh and Anapsos combined avoids this inhibitory effect. Thus, Anapsos modulates the immune response against ESFh in naive mice and on the nitrite production in prestimulated rat aveolar macrophages.
机译：已知Fasciola hepatica hepatica（ESFh）的排泄/分泌抗原会触发类似Th2的免疫反应。 Anapsos（A）是从蕨白菜蕨的根茎中获得的水溶性提取物，在某些寄生虫感染和免疫学疾病中显示出免疫调节作用。在这项工作中，我们评估了Anapsos和ESFh和Quillaja saponaria提取物（Qs）对BALB / c小鼠和大鼠肺泡巨噬细胞的影响。与ESFh和Qs + ESFh处理的组相比，Anapsos调节了用ESFh免疫的小鼠的反应，降低了A + ESFh-和A + Qs + ESFh处理的小鼠的IgG抗体，并触发了脾细胞培养物中高水平的γIFN 。此外，与仅用LPS刺激的巨噬细胞相比，Anapsos对用脂多糖（LPS）以及ESFh抗原预刺激的大鼠肺泡巨噬细胞的亚硝酸盐产生具有统计学意义的抑制作用。 ESFh和Anapsos的联合使用避免了这种抑制作用。因此，Anapsos调节了天真小鼠中针对ESFh的免疫应答以及预先刺激的大鼠肺泡巨噬细胞中亚硝酸盐生成的免疫应答。

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