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首页> 外文期刊>Journal of Parasitology >Single-dose metronidazole clears Opalina sp. from juvenile Bufo woodhousii.
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Single-dose metronidazole clears Opalina sp. from juvenile Bufo woodhousii.

机译：单剂量甲硝唑清除Opalina sp。来自青少年Bufo woodhousii。

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摘要

Protozoans of the family Opalinidae are intestinal commensals in amphibians. To test the hypothesis that these organisms are susceptible to the antiprotozoal antibiotic metronidazole, we randomly assigned 60 juvenile Woodhouse's toads (Bufo woodhousii) to receive a single oral dose of metronidazole or water. In pilot trials, the prevalence of opalinids in untreated members of this population was over 70%. One-third of the study population was dissected at each of 3 time points: 18 hr, 1 wk, and 2 wk post-treatment. An examiner blinded to the toad's treatment history determined the presence or absence of opalinids using a dissecting microscope. Opalinids were found in 3/10 toads in the treatment group and 9/10 in the control group after 18 hr (P<0.02), in none of the treatment group and 8/10 in the control group after 1 wk (P<0.001), and in none of the treatment group and 10/10 in the control group after 2 wk (P<0.0001). These results suggest that a single-dose of metronidazole quickly and reliably clears opalinids from juvenile Woodhouse's toads with no evidence of short-term recurrence. The treatment was well tolerated, with no apparent morbidity and no mortality in either group. Future exploration of opalinid-related host fitness consequences may be facilitated by this simple method of developing a protozoan-free host population.
机译：Opalinidae科的原生动物是两栖动物的肠道共生。为了检验这些生物对抗原生动物的甲硝唑敏感的假说，我们随机分配了60只Woodhouse蟾蜍（Bufo woodhousii）接受一次口服甲硝唑或水的剂量。在试点试验中，该人群未经治疗的人中不透明脂质的患病率超过70％。在以下三个时间点分别解剖三分之一的研究人群：治疗后18小时，1周和2周。一位对蟾蜍的治疗史视而不见的检查员使用解剖显微镜确定了是否存在不透明脂质。 18小时后，在治疗组中3/10蟾蜍中发现了阿片类药物，在对照组中发现了9/10（P <0.02），在1周后未发现任何治疗组中的阿片类药物，在对照组中发现了8/10（P <0.001）。 ），治疗2周后均无治疗组和对照组10/10（P <0.0001）。这些结果表明，单剂量甲硝唑可快速可靠地清除幼龄Woodhouse蟾蜍中的不透明油脂，而没有短期复发的迹象。该治疗耐受性良好，两组均无明显发病率和死亡率。通过开发无原生动物宿主种群的这种简单方法，可以促进对与不透明脂质相关的宿主适应性后果的进一步探索。

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