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首页> 外文期刊>Journal of Parasitology >GENOTYPE-ASSOCIATED ARGINASE 1 EXPRESSION IN RAT PERITONEAL MACROPHAGES INDUCED BY TOXOPLASMA GONDII
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GENOTYPE-ASSOCIATED ARGINASE 1 EXPRESSION IN RAT PERITONEAL MACROPHAGES INDUCED BY TOXOPLASMA GONDII

机译:基因型相关的精氨酸酶1在弓形虫诱导的大鼠腹膜巨噬细胞中的表达

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摘要

Toxoplasma gondii induces polarization of mouse macrophages, including both classically activated macrophages (M1) and alternatively activated macrophages (M2) in a genotype-related manner. Here we present a novel result that the Wh6 strain with type Chinese 1, which is predominantly prevalent in China, induces Arg1 expression in a STAT6-dependent manner in primary rat peritoneal macrophages as compared to the PRU stain with type II, which elicited a high expression of Arg1 in a C/EBP beta-dependent manner. In addition, dexamethasone inhibited Arg1 expression in rat macrophages in both treatments. Our data suggest that Arg1 expression, which is abundant in polarized M2 cells, is associated with strain/genotype differences from different pathways.
机译:弓形虫以基因型相关的方式诱导小鼠巨噬细胞极化,包括经典激活的巨噬细胞(M1)和交替激活的巨噬细胞(M2)。在这里,我们提出了一个新的结果,即与中国II型的PRU染色相比,中国第一型的Wh6菌株以STAT6依赖性方式在原代大鼠腹膜巨噬细胞中诱导Arg1表达,这在中国很普遍。 C / EBP beta依赖性方式表达Arg1。此外,在两种治疗中,地塞米松均抑制大鼠巨噬细胞中Arg1的表达。我们的数据表明,在极化的M2细胞中丰富的Arg1表达与来自不同途径的菌株/基因型差异相关。

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