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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Decreased lamina propria effector cell responsiveness to interleukin-10 in ileal Crohn's disease.
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Decreased lamina propria effector cell responsiveness to interleukin-10 in ileal Crohn's disease.

机译：回肠克罗恩病中固有层效应细胞对白介素10的反应性降低。

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We investigated whether a lack of IL-10 production or responsiveness could be involved in Crohn's disease pathogenesis. Lamina propria mononuclear cells, isolated from the ilea of Crohn's disease patients (n = 16) and controls (n = 13), were activated with anti-CD3 mAb in the presence of CD80 transfectants or LPS +/- IFN-gamma. No evidence for deficient IL-10 production by either T cells or macrophages in Crohn's disease was found. However, the efficacy of rhIL-10 to down-regulate IFN-gamma and especially TNF production in cell cultures from the involved tissues of Crohn's disease patients was poor, and the use of an anti-IL-10R mAb even provided evidence for proinflammatory effects of IL-10. This lack of IL-10 effect possibly results from IL-12 activity. We conclude that IL-10 exhibits poor anti- and even potential proinflammatory effects on ileal Crohn's disease lamina propria. These data might explain the lack of therapeutic efficacy when IL-10 is given to Crohn's disease patients. (c)2001 Elsevier Science.
机译：我们调查了缺乏IL-10的产生或反应性可能与克罗恩病的发病机理有关。在CD80转染子或LPS +/-IFN-γ存在下，用抗CD3 mAb激活从克罗恩病患者（n = 16）和对照（n = 13）的回肠中分离的固有层单核细胞。没有发现在克罗恩病中由T细胞或巨噬细胞产生不足的IL-10的证据。然而，rhIL-10下调克罗恩病患者相关组织细胞培养物中IFN-γ尤其是TNF产生的效果很差，抗IL-10R mAb的使用甚至提供了促炎作用的证据IL-10。 IL-10缺乏作用可能是由于IL-12活性引起的。我们得出结论，IL-10对回肠克罗恩病固有层的抗炎作用甚至潜在的促炎作用。这些数据可能解释了当对克罗恩病患者使用IL-10时缺乏治疗功效。 （c）2001 Elsevier科学。

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