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首页> 外文期刊>Journal of Parasitology >DETECTION OF EHRLICHIA CANIS, BABESIA VOGELI, AND TOXOPLASMA GONDII DNA IN THE BRAIN OF DOGS NATURALLY INFECTED WITH LEISHMANIA INFANTUM
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DETECTION OF EHRLICHIA CANIS, BABESIA VOGELI, AND TOXOPLASMA GONDII DNA IN THE BRAIN OF DOGS NATURALLY INFECTED WITH LEISHMANIA INFANTUM

机译：天然感染了利什曼原虫的狗脑中埃希氏大肠杆菌，巴贝斯小肠和弓形虫DNA的检测

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摘要

The aims of this study were to investigate the presence of Leishmania infantum and possible co-infection with Anaplasma platys, Babesia vogeli, Ehrlichia canis, and Toxoplasma gondii in the brain of 24 dogs naturally infected by L. infantum. A total of 24 mongrel adult dogs (22 clinically affected, 2 with neurological signs, and 2 subclinically infected) aged between 2 and 5 yr, naturally infected by visceral leishmaniasis, were selected. Fragments from meninges, frontal cortex, thalamus, cerebellum, and choroid plexus of the lateral ventricles and fourth ventricle were collected, mixed, and tested by real-time polymerase chain reaction (qPCR). Leishmania infantum DNA was detected in 95.8% (23/24) of the infected dogs, including the subclinically infected. A total of 14/24 (58.3%) dogs were co-infected by E. canis and L. infantum, 4/24 (16.7%) were co-infected by E. canis, B. vogeli, and L. infantum, 2/24 (8.3%) were co-infected by B. vogeli and L. infantum, and 1/24 (4.2%) dog was co-infected by E. canis, B. vogeli, T. gondii, and L. infantum. All 24 brain samples tested negative for A. platys. These results demonstrate that L. infantum is able to penetrate into the brain parenchyma, either alone or in association to other zoonotic pathogens. In addition, qPCR could be considered for adequate evaluation of Leishmania in the brain tissue of dogs with neurological signs that have died.
机译：这项研究的目的是调查24只自然感染了婴儿乳杆菌的狗的大脑中是否存在婴儿利什曼原虫以及可能与板状无浆膜，贝贝虫（Babesia vogeli），犬埃里希氏犬（Ehrlichia canis）和弓形虫共感染。选择了24只杂种成年狗（22只临床受影响，2只具有神经系统症状，2只亚临床感染），年龄2至5岁，自然被内脏利什曼病感染。收集，混合混合脑膜，额叶皮层，丘脑，小脑和侧脑室和第四脑室的脉络丛的片段，进行混合，并通过实时聚合酶链反应（qPCR）进行测试。在包括亚临床感染的95.8％（23/24）的感染犬中检测到婴儿利什曼原虫DNA。总共14/24（58.3％）的狗被犬埃里希氏菌和婴儿乳杆菌共同感染，4/24（16.7％）的狗犬埃希氏菌，B。vogeli和婴儿乳杆菌2共同感染。 / 24（8.3％）被B. vogeli和L. infantum共同感染，1/24（4.2％）的狗被E. canis，B. vogeli，T. gondii和L. infantum共同感染。所有24个脑样本均检测为鸭状杆菌阴性。这些结果表明，婴儿乳杆菌能够单独或与其他人畜共患病原体结合进入脑实质。另外，可以考虑使用qPCR对具有死亡神经症状的狗的脑组织中的利什曼原虫进行充分评估。

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