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首页> 外文期刊>Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry >Simple and efficient radiolabeling of hyaluronic acid and its in vivo evaluation via oral administration
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Simple and efficient radiolabeling of hyaluronic acid and its in vivo evaluation via oral administration

机译：透明质酸的简单有效放射标记及其口服给药的体内评价

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The aim of this study was to synthesize hyaluronic acid-tyramine (HA-Tm) conjugate and label it with radioisotopes for in vivo biodistribution study. Radiolabeling of HA-Tm was carried out using I-125 and I-131 and the observed radiochemical yield were 96 and 98 % respectively. Biodistribution study of radiolabeled HA-Tm was performed with normal Balb/c mice via oral administration. The uptake values of [I-131]HA-Tm in organs were measured by gamma-counter at different time points. Biodistribution results showed that most radioactivities were observed in the gastrointestinal tract at initial time point. A small part of [I-131]HA-Tm was then absorbed into the bloodstream from the small intestine and distributed in some organs. SPECT/CT images of orally administered [I-125]HA-Tm were well matched with the biodistribution data. The results in the present study would provide an efficient radiolabeling method of hyaluronic acid and also present quantitative organ distributions of orally administered HA.
机译：这项研究的目的是合成透明质酸-酪胺（HA-Tm）共轭物，并用放射性同位素标记它，用于体内生物分布研究。使用I-125和I-131对HA-Tm进行放射性标记，观察到的放射化学产率分别为96％和98％。正常口服Balb / c小鼠通过口服给药进行了放射性标记HA-Tm的生物分布研究。通过γ计数器在不同时间点测量器官中[I-131] HA-Tm的摄取值。生物分布结果表明，在初始时间点在胃肠道中观察到大多数放射性。然后，一小部分[I-131] HA-Tm从小肠吸收到血液中，并分布在一些器官中。口服[I-125] HA-Tm的SPECT / CT图像与生物分布数据完全匹配。本研究的结果将提供透明质酸的有效放射性标记方法，并且还可以提供口服HA的定量器官分布。

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