Synthesis and characterization of Ga-68 labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI)

Cho Bo-Bae; Park Jeong Hoon; Jung Soon Jae; Lee JunYoung; Lee Jung Hoon; Hur Min Goo; Raj C. Justin; Yu Kook-Hyun

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Synthesis and characterization of Ga-68 labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI)

机译：Ga-68标记的Fe3O4纳米粒子的合成与表征，用于正电子发射断层扫描（PET）和磁共振成像（MRI）

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We designed a Ga-68 labeled Fe3O4 nano-biocomposite for dual applications as diagnostic imaging agent in positron emission tomography (PET)/magnetic resonance imaging (MRI). The nano-biocomposites ((GaNHFCNP)-Ga-68) were fabricated via surface modified iron oxide nanoparticles and NOTA as bi-functional chelating agent with Ga-68 isotopes from Ge-68/Ga-68 generator. The structure and morphological properties of nano-biocomposite was characterized by XRD, TEM and IR analysis. (68)GaNHFCNPs exhibits very low cytotoxicity and high cellular uptake upon SK-BR-3 and CT-26 cell lines. The advantages of high biocompatibility, magnetism and cell uptake make this composite promising as a potential probe of PET/MRI for effective detection of cancer.

机译：我们设计了一种Ga-68标记的Fe3O4纳米生物复合材料，可在正电子发射断层扫描（PET）/磁共振成像（MRI）中作为诊断成像剂双重应用。通过表面修饰的氧化铁纳米粒子和作为双功能螯合剂的NOTA与来自Ge-68 / Ga-68发生器的Ga-68同位素制备了纳米生物复合材料（（GaNHFCNP）-Ga-68）。通过XRD，TEM和IR分析表征了纳米生物复合材料的结构和形貌。（68）GaNHFCNP对SK-BR-3和CT-26细胞系表现出非常低的细胞毒性和高细胞摄取。高生物相容性，磁性和细胞吸收的优势使这种复合材料有望成为有效检测癌症的PET / MRI潜在探针。

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《Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry》 |2015年第1期|共10页
作者
Cho Bo-Bae; Park Jeong Hoon; Jung Soon Jae; Lee JunYoung; Lee Jung Hoon; Hur Min Goo; Raj C. Justin; Yu Kook-Hyun;
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正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
关键词
Iron oxide nanoparticles; Ga-68; Dual modality; Positron emission tomography; Magnetic resonance imaging;

机译：氧化铁纳米粒子;Ga-68;双模态;正电子发射断层扫描;磁共振成像;

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1. Synthesis and characterization of Ga-68 labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI) [J] . Cho Bo-Bae, Park Jeong Hoon, Jung Soon Jae, Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry . 2015,第1期

机译：Ga-68标记的Fe3O4纳米粒子的合成与表征，用于正电子发射断层扫描（PET）和磁共振成像（MRI）
2. Positron emission tomography/magnetic resonance hybrid scanner imaging of cerebral blood flow using O-15-water positron emission tomography and arterial spin labeling magnetic resonance imaging in newborn piglets [J] . Andersen Julie B., Henning William S., Lindberg Ulrich, Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2015,第11期

机译：使用O-15-水正电子发射断层扫描和动脉自旋标记磁共振成像对新生仔猪的脑血流进行正电子发射断层扫描/磁共振混合扫描仪成像
3. Coregistered whole body magnetic resonance imaging-positron emission tomography (MRI-PET) versus PET-computed tomography plus brain MRI in staging resectable lung cancer: Comparisons of clinical effectiveness in a randomized trial [J] . YiC.A., LeeK.S., LeeH.Y., Cancer: A Journal of the American Cancer Society . 2013,第10期

机译：共注册的全身磁共振成像-正电子发射断层扫描（MRI-PET）与PET计算机断层扫描加脑MRI在分期可切除肺癌中的比较：一项随机试验的临床疗效比较
4. Title: The integration of magnetic resonance imaging (MRI) and positron emission tomography (PET) will transform medical imaging [C] . Prato, Frank S., Thompson, R.Terry, Butler, John, URSI General Assembly and Scientific Symposium . 2014

机译：标题：磁共振成像（MRI）和正电子发射断层扫描（PET）的集成将改变医学成像
5. Development and analysis of radiolabeled magnetic nanoparticles for positron emission tomography and magnetic resonance imaging [D] . Glaus, Charles R. M. 2008

机译：用于正电子发射断层扫描和磁共振成像的放射性标记磁性纳米颗粒的开发和分析
6. Positron emission tomography/magnetic resonance hybrid scanner imaging of cerebral blood flow using 15O-water positron emission tomography and arterial spin labeling magnetic resonance imaging in newborn piglets [O] . Julie B Andersen, William S Henning, Ulrich Lindberg, 2015

机译：15O-水正电子发射断层扫描和动脉自旋标记磁共振成像对新生仔猪脑血流的正电子发射断层扫描/磁共振混合扫描仪成像
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机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Synthesis and characterization of Ga-68 labeled Fe3O4 nanoparticles for positron emission tomography (PET) and magnetic resonance imaging (MRI)

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