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首页> 外文期刊>Journal of Radioanalytical and Nuclear Chemistry: An International Journal Dealing with All Aspects and Applications of Nuclear Chemistry >Evaluation of cholesterol absorption inhibition of Anti-NPC1L1 IgY by [H-3]-labeled cholesterol in Sprague-Dawley rats
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Evaluation of cholesterol absorption inhibition of Anti-NPC1L1 IgY by [H-3]-labeled cholesterol in Sprague-Dawley rats

机译：[H-3]标记的胆固醇在Sprague-Dawley大鼠中评估抗NPC1L1 IgY的胆固醇吸收抑制

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摘要

This research was conducted to assess the ability of [H-3]-cholesterol by co-administered Anti-NPC1L1 (Niemann-Pick C1-Like 1) IgY for measuring the absorption of cholesterol and to evaluate the efficacy of Anti-NPC1L1 IgY as a cholesterol absorption inhibitor in Sprague-Dawley rats model. The rats were administered with Anti-NPC1L1 IgY, ezetimibe as positive control and yolk powder as vehicle control. Systemic blood, feces, urine and intestine were sampled and the concentration of cholesterol was determined by means of radioactivity. The results indicate that the evaluation of cholesterol absorption inhibition was successfully performed by [H-3]-cholesterol. Meanwhile, the administration of Anti-NPC1L1 IgY inhibits cholesterol absorption in Sprague-Dawley rats significantly.
机译：进行这项研究是为了评估抗NPC1L1（Niemann-Pick C1-Like 1）IgY并用的[H-3]-胆固醇测量胆固醇吸收的能力，并评估抗NPC1L1 IgY的疗效Sprague-Dawley大鼠模型中的胆固醇吸收抑制剂。给大鼠施用抗-NPC1L1 IgY，依泽替米贝作为阳性对照和蛋黄粉作为媒介物对照。采集全身血液，粪便，尿液和肠道样本，并通过放射性测定胆固醇的浓度。结果表明，通过[H-3]-胆固醇成功地进行了胆固醇吸收抑制的评价。同时，抗NPC1L1 IgY的给药显着抑制Sprague-Dawley大鼠的胆固醇吸收。

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