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首页> 外文期刊>Journal of separation science. >Evaluation of matrix effects in different multipesticide residue analysis methods using liquid chromatography-tandem mass spectrometry, including an automated two-dimensional cleanup approach
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Evaluation of matrix effects in different multipesticide residue analysis methods using liquid chromatography-tandem mass spectrometry, including an automated two-dimensional cleanup approach

机译：使用液相色谱-串联质谱法（包括自动二维清除方法）评估不同农药残留分析方法中基质的影响

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摘要

Pesticide residue analysis is an important part of food quality control. Three of the most widely used methods are the DFG S19 (extraction with acetone), the ChemElut method (extraction with methanol), and QuEChERS (quick, easy, cheap, effective, rugged, safe; acetonitrile-based). Despite many developments in the field of sample preparation, matrix effects are still one of the most disturbing problems in routine analysis. In this study, we compare the matrix effects in LC-MS analysis after using these three methods in pesticide analysis. Using postcolumn infusion, we were able to visualize all suppressions over the whole chromatogram in matrix-effect profiles. Recently, we also presented a system for the determination of up to 300 pesticides from various kinds of fruit and vegetables. For the measurement, we injected an aliquot of a raw acetonitrile extract. The subsequent cleanup was carried out fully automated by a multidimensional LC. Matrix compounds and analytes are separated in the first dimension on a hydrophilic interaction LC column. In this study, we also compared this new approach with the classical methods. The matrix-effect profiles showed less suppression with the hydrophilic interaction LC-based cleanup. A final evaluation of the partitioning steps of all methods confirmed the benefits of the chromatographic cleanup approach.
机译：农药残留分析是食品质量控制的重要组成部分。三种最广泛使用的方法是DFG S19（用丙酮萃取），ChemElut方法（用甲醇萃取）和QuEChERS（快速，简便，廉价，有效，坚固，安全;基于乙腈）。尽管在样品制备领域取得了许多进展，但是基质效应仍然是常规分析中最令人困扰的问题之一。在这项研究中，我们比较了在农药分析中使用这三种方法后，LC-MS分析中的基质效应。使用柱后输注，我们能够在基质效应图谱中可视化整个色谱图上的所有抑制。最近，我们还提出了一种用于测定各种水果和蔬菜中多达300种农药的系统。为了进行测量，我们注入了乙腈粗提物的等分试样。随后的清理是通过多维LC全自动进行的。基质化合物和分析物在亲水相互作用LC色谱柱上以第一维分离。在这项研究中，我们还将这种新方法与经典方法进行了比较。基质效应曲线显示基于亲水性相互作用的LC清除具有较少的抑制作用。所有方法分配步骤的最终评估证实了色谱净化方法的好处。

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