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首页> 外文期刊>Clinical Endocrinology >Polymorphisms of the ghrelin/obestatin gene and ghrelin levels in Chinese children with short stature.
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Polymorphisms of the ghrelin/obestatin gene and ghrelin levels in Chinese children with short stature.

机译：生长激素/肥胖抑素基因多态性和中国身材矮小儿童的生长素释放肽水平。

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OBJECTIVE: To investigate the role of ghrelin and polymorphisms of ghrelin/obestatin gene in children with short stature. METHODS: A total of 117 GH deficient (GHD) and 81 idiopathic short stature (ISS) children were studied. The controls consisted of 125 age and gender-matched healthy children. The Arg51Gln, Leu72Met and Gln90Leu polymorphisms were genotyped using MassArray and total plasma ghrelin was measured by radioimmunoassay. RESULTS: In this study, the frequency of the Arg51Gln polymorphism was very low (0% in controls and 1.0% in patients). The frequency of the Gln90Leu polymorphism was 1.6% in controls and 0.5% in patients, respectively. Higher frequencies of Leu72Met (34.4% in controls and 39.9% in patients) and Met72Met genotypes (4.0% in controls and 2.0% in patients) were found. The differences in the Arg51Gln, Leu72Met or Gln90Leu genotypes and allele frequencies between patients and controls were not significant. Also, there were no significant differences in the Leu72Met genotypes and allele frequencies between GHD and ISS subgroups. There were no significant differences in clinical characteristics and biochemistry markers (including ghrelin levels) among the different genotypes of Leu72Met. However, plasma ghrelin levels in the GHD group were significantly lower than those of controls (P = 0.001). CONCLUSION: These results suggest that ghrelin may have a role in GH secretion and controlling growth. Lower ghrelin levels, but not ghrelin/obestatin polymorphism, might contribute to GHD.
机译：目的：探讨生长激素释放肽和生长激素释放肽/奥贝他汀基因多态性在矮小儿童中的作用。方法：共研究了117名GH缺乏症（GHD）和81名特发性矮身材（ISS）儿童。对照组由125名年龄和性别匹配的健康儿童组成。使用MassArray对Arg51Gln，Leu72Met和Gln90Leu多态性进行基因分型，并通过放射免疫测定法测定总血浆生长素释放肽。结果：在这项研究中，Arg51Gln多态性的频率非常低（对照组为0％，患者为1.0％）。 Gln90Leu多态性的频率在对照组中为1.6％，在患者中为0.5％。发现较高的Leu72Met频率（对照组为34.4％，患者为39.9％）和Met72Met基因型（对照组为4.0％，患者为2.0％）。患者与对照之间的Arg51Gln，Leu72Met或Gln90Leu基因型和等位基因频率的差异不显着。同样，GHD和ISS亚组之间Leu72Met基因型和等位基因频率也没有显着差异。 Leu72Met的不同基因型之间在临床特征和生化指标（包括生长素释放肽水平）上没有显着差异。但是，GHD组的血浆生长素释放肽水平显着低于对照组（P = 0.001）。结论：这些结果表明生长素释放肽可能在GH分泌和控制生长中起作用。 ghrelin水平较低，但ghrelin / obestatin多态性可能不高，可能有助于GHD。

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