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首页> 外文期刊>Journal of shoulder and elbow surgery >Intra-articular changes precede extra-articular changes in the biceps tendon after rotator cuff tears in a rat model
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Intra-articular changes precede extra-articular changes in the biceps tendon after rotator cuff tears in a rat model

机译：在大鼠模型中，肩袖撕裂后，二头肌腱的关节内变化先于二头肌腱的关节外变化

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Hypothesis: Biceps tendon pathology is common with rotator cuff tears. The mechanisms for biceps changes, and therefore its optimal treatment, are unknown. Our objective was to determine the effect of rotator cuff tears on regional biceps tendon pathology. We hypothesized that histologic and compositional changes would appear before organizational changes, both would appear before mechanical changes, and changes would begin at the tendon's insertion site. Materials and methods: Detachment of supraspinatus and infraspinatus tendons or sham surgery was done in 65 Sprague-Dawley rats. Rats were euthanized at 1, 4, or 8 weeks for regional measurements of histologic, compositional, organizational (1, 4 and 8 weeks), or mechanical properties (4 and 8 weeks only). Results: One week after tendon detachments, decreased organization and more rounded cell shape were found in the intra-articular space of the biceps tendon. Aggrecan expression was increased along the entire length of the tendon, whereas all other compositional changes were only at the tendon's proximal insertion into bone. With time, this disorganization and more rounded cell shape extended the length of the tendon. Organizational and cell shape changes also preceded detrimental mechanical changes: decreased modulus in the intra-articular space was found after 8 weeks. Conclusions: Results support a degenerative component to pathology in the biceps tendon. In addition, changes resembling a tendon exposed to compressive loading occurring first in the intra-articular space indicate that the biceps tendon plays an increased role as a load-bearing structure against the humeral head in the presence of rotator cuff tears.
机译：假设：二头肌腱病变常见于肩袖撕裂。二头肌改变的机制及其最佳治疗方法尚不清楚。我们的目的是确定肩袖撕裂对区域二头肌腱病理的影响。我们假设组织学和成分的改变将在组织改变之前出现，两者都将在机械改变之前出现，并且改变将在肌腱的插入部位开始。材料和方法：在65只Sprague-Dawley大鼠中进行了棘上肌和棘下肌腱的分离或假手术。在第1、4或8周对大鼠实施安乐死，以进行组织学，成分，组织（1、4和8周）或机械特性（仅4和8周）的区域测量。结果：腱脱离一周后，二头肌腱的关节腔内组织减少，细胞形状更圆滑。 Aggrecan的表达沿整个肌腱长度增加，而所有其他组成变化仅在肌腱的近端插入骨中时才发生。随着时间的流逝，这种混乱和更加圆润的细胞形状延长了肌腱的长度。组织和细胞形状的变化也早于有害的机械变化：8周后发现关节腔内模量下降。结论：结果支持肱二头肌肌腱病理性退变。此外，类似于肌腱暴露于关节腔内首先受到压缩负荷的变化表明，在存在肩袖撕裂的情况下，肱二头肌腱对肱骨头的承重结构起着增加的作用。

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