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首页> 外文期刊>Journal of shoulder and elbow surgery >Increased vascularization during early healing after biologic augmentation in repair of chronic rotator cuff tears using autologous leukocyte- and platelet-rich fibrin (L-PRF): A prospective randomized controlled pilot trial
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Increased vascularization during early healing after biologic augmentation in repair of chronic rotator cuff tears using autologous leukocyte- and platelet-rich fibrin (L-PRF): A prospective randomized controlled pilot trial

机译：使用自体白细胞和富含血小板的纤维蛋白（L-PRF）修复慢性肩袖撕裂的生物学增强后，早期愈合过程中血管生成增加：一项前瞻性随机对照试验

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Hypothesis: We hypothesized that arthroscopic rotator cuff repairs using leukocyte- and platelet-rich fibrin (L-PRF) in a standardized, modified protocol is technically feasible and results in a higher vascularization response and watertight healing rate during early healing. Methods: Twenty patients with chronic rotator cuff tears were randomly assigned to 2 treatment groups. In the test group (N = 10), L-PRF was added in between the tendon and the bone during arthroscopic rotator cuff repair. The second group served as control (N = 10). They received the same arthroscopic treatment without the use of L-PRF. We used a double-row tension band technique. Clinical examinations including subjective shoulder value, visual analog scale, Constant, and Simple Shoulder Test scores and measurement of the vascularization with power Doppler ultrasonography were made at 6 and 12 weeks. Results: There have been no postoperative complications. At 6 and 12 weeks, there was no significant difference in the clinical scores between the test and the control groups. The mean vascularization index of the surgical tendon-to-bone insertions was always significantly higher in the L-PRF group than in the contralateral healthy shoulders at 6 and 12 weeks ( P = .0001). Whereas the L-PRF group showed a higher vascularization compared with the control group at 6 weeks ( P = .001), there was no difference after 12 weeks of follow-up ( P = .889). Watertight healing was obtained in 89% of the repaired cuffs. Discussion/Conclusions: Arthroscopic rotator cuff repair with the application of L-PRF is technically feasible and yields higher early vascularization. Increased vascularization may potentially predispose to an increased and earlier cellular response and an increased healing rate.
机译：假设：我们假设使用标准化的，改良的方案中的白细胞和富含血小板的纤维蛋白（L-PRF）进行关节镜下旋转袖套修复在技术上是可行的，并且在早期治愈期间会导致更高的血管形成反应和不透水的治愈率。方法：将20例慢性肩袖撕裂患者随机分为2个治疗组。在测试组（N = 10）中，在关节镜检查旋转袖套修复过程中，在肌腱和骨骼之间添加了L-PRF。第二组作为对照（N = 10）。他们接受了相同的关节镜治疗，没有使用L-PRF。我们使用了双排张力带技术。在第6周和第12周进行临床检查，包括主观肩膀值，视觉模拟量表，恒定和简单肩膀测试评分以及用功率多普勒超声检查血管化程度。结果：没有术后并发症。在第6周和第12周，测试组和对照组之间的临床评分没有显着差异。 L-PRF组在第6周和第12周时，手术肌腱至骨插入物的平均血管生成指数始终显着高于对侧健康肩膀（P = .0001）。 L-PRF组在第6周时的血管化程度高于对照组（P = .001），但在随访12周后无差异（P = .889）。 89％的修复袖口实现了水密愈合。讨论/结论：应用L-PRF进行关节镜下肩袖修复在技术上是可行的，并且早期血管生成更高。增加的血管形成可能潜在地导致增加的和较早的细胞应答以及增加的治愈率。

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