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首页> 外文期刊>Journal of speech, language, and hearing research: JSLHR >Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia
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Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia

机译：语言和语音错误的失用症在原发性进行性失语的非流利性/语法性和低语性变异的诊断中

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Purpose: The International Consensus Criteria for the diagnosis of primary progressive aphasia (PPA; Gorno-Tempini et al., 2011) propose apraxia of speech (AOS) as 1 of 2 core features of nonfluent/agrammatic PPA and propose phonological errors or absence of motor speech disorder as features of logopenic PPA. We investigated the sensitivity and specificity of AOS and phonological errors as markers for these variants and also investigated the relationship between AOS, phonological errors, and findings on C-labeled Pittsburgh Compound B (PiB)-positron emission tomography (PET) imaging associated with putative Alzheimer-type pathology. Method: Connected speech and word repetition in 23 people with PPA who underwent PiB-PET imaging were rated for apraxic versus phonological disruption by 1 rater who was blind to diagnosis and by 2 raters who were blind to PiB-PET results. Results: Apraxic characteristics had high sensitivity for nonfluent/ agrammatic PPA, and phonological errors had high sensitivity for logopenic PPA; however, phonological errors showed lower specificity for logopenic PPA. On PiB imaging, 8 of 9 people with predominant AOS returned negative results, whereas participants with no or questionable AOS with and without phonological errors returned positive results. Conclusions: Attention to AOS and phonological errors may help counter some of the inherent limitations of diagnosis-byexclusion in the current International Consensus Criteria for diagnosing PPA.
机译：目的：诊断原发性进行性失语的国际共识标准（PPA; Gorno-Tempini等，2011）提出言语失用症（AOS）是非流利/文法性PPA的两个核心特征之一，并提出语音错误或缺乏运动性语言障碍是低聚PPA的特征。我们调查了AOS的敏感性和特异性以及作为这些变体标记的语音错误，并且还研究了AOS，语音错误和C标记匹兹堡化合物B（PiB）-正电子发射断层扫描（PET）影像学与推定相关的发现之间的关系阿尔茨海默氏病类型。方法：对23名接受PiB-PET成像的PPA患者进行言语和单词重复连接，根据1名对诊断不知情的评估者和2名对PiB-PET结果不知情的评估者，将其言语扰乱与语音破坏联系在一起。结果：四肢特征对非流利/语法性PPA敏感度高，语音错误对低密度PPA敏感度高。但是，语音错误显示出对低密度PPA的特异性较低。在PiB成像中，AOS占优势的9人中有8人返回阴性结果，而AOS没有或有疑问且有和没有语音错误的参与者则返回了阳性结果。结论：注意AOS和语音错误可能有助于克服当前诊断PPA的国际共识标准中的排除诊断固有的局限性。

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