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首页> 外文期刊>Journal of speech, language, and hearing research: JSLHR >Maturation of speech and language functional neuroanatomy in pediatric normal controls.
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Maturation of speech and language functional neuroanatomy in pediatric normal controls.

机译：小儿正常对照者的言语和语言功能神经解剖结构的成熟度。

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PURPOSE: This study explores the relationship between age and resting-state regional cerebral blood flow (rCBF) in regions associated with higher order language skills using a population of normal children, adolescents, and young adults. METHOD: rCBF was measured in 33 normal participants between the ages of 7 and 19 years using single photon emission computed tomography. Participants' ages were regressed on rCBF values (normalized to whole-brain CBF) in 2 ways: (a) within anatomically defined, language-related regions of interest (ROIs) including Wernicke's area, Broca's area, angular gyrus, planum temporale, and Heschl's gyrus and (b) within clusters of voxels found to be significantly related to age in voxel-wise analyses. RESULTS: rCBF in all anatomically defined ROIs except Heschl's gyrus declined as a function of age. Additionally, voxel-wise analyses revealed clusters where rCBF declined with age in left inferior parietal, left superior temporal, and right middle temporal regions-areas often implicated in higher order language functions. CONCLUSIONS: These data suggest that ongoing maturation (e.g., dendritic pruning) in higher order cognitive areas (e.g., angular gyrus) continues into adolescence, as reflected by declining rCBF, while the primary auditory area (Heschl's gyrus) has become a stable neuronal population by age 7 years.
机译：目的：本研究使用正常儿童，青少年和年轻人群，探讨与高阶语言技能相关的区域中年龄与静止状态区域脑血流量（rCBF）之间的关系。方法：使用单光子发射计算机体层摄影术对7到19岁之间的33名正常参与者进行了rCBF测量。参与者的年龄以两种方式根据rCBF值回归（标准化为全脑CBF）：（a）在解剖学上定义的，与语言相关的感兴趣区域（ROI）内，包括Wernicke区域，Broca区域，角回，平面颞叶和在体素分析中，Heschl的回和（b）体素簇内的年龄与年龄显着相关。结果：除Heschl的回旋随年龄而下降外，所有解剖学定义的ROI中的rCBF均下降。此外，按体素进行的分析显示出簇，其中左下顶壁，左上颞叶和右中颞叶区域的rCBF随着年龄的增长而下降-这些区域通常与高级语言功能有关。结论：这些数据表明，较高的认知区域（例如，角回）的持续成熟（例如，树突状修剪）持续进入青春期，这反映出rCBF的下降，而主要听觉区域（赫氏回）已成为稳定的神经元群体。到7岁为止。

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