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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations
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Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations

机译：三七总皂苷通过药物组合拮抗皮层提取物诱导的三七总皂苷分泌儿茶酚胺

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摘要

Ethnopharmacological relevance: Traditional Chinese Medicine (TCM) operates on the general principle that compatible components of different herbal decoction may work together to synergistically enhance therapeutic efficacy or reduce adverse effects. Cortex Periplocae is an herb that has been used in TCM clinics for a long time in the treatment of chronic heart failure. However, recently, the use of this herb has been restricted because of widespread abuse and misapplications. Radix Notoginseng is another herb that is used in TCM because of its protective role on cardiomyocytes. From our previous studies on these two herbs in a mouse model, we observed an increased LD50 after oral administration of Cortex Periplocae extract (CPE) and Panax notoginseng saponins (PNS) in a ratio of 1:1 compared with Cortex Periplocae extract used alone.
机译：民族药理学相关性：中药（TCM）的一般原则是不同草药汤剂的相容成分可以协同工作，以协同增效治疗效果或减少不良反应。 tex皮（Cortex Periplocae）是一种在中医诊所长期使用的草药，用于治疗慢性心力衰竭。但是，由于广泛的滥用和误用，最近限制了这种草药的使用。三七是另一种用于中药的草药，因为它对心肌细胞具有保护作用。从我们先前在小鼠模型中对这两种草药的研究来看，与单独使用皮质中提取物相比，口服皮质中提取物（CPE）和三七总皂苷（PNS）比例为1：1时，LD50增加。

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