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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >The anti-arthritic effects of Aconitum vilmorinianum, a folk herbal medicine in Southwestern China
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The anti-arthritic effects of Aconitum vilmorinianum, a folk herbal medicine in Southwestern China

机译：西南地区民间草药乌头乌头的抗关节炎作用

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摘要

Ethnopharmacological relevance: Aconiti Radix (AC) and Aconiti Kusnezoffii Radix (AK) are two traditional Chinese medicines commonly used to treat joint pain and arthritis. In Southwestern China, Huangcaowu (AV), the root of Aconitum vilmorinianum Kom.; has long been used as a local substitute for these herbs for analgesia and anti-inflammation. However, its anti-arthritic effects have not been investigated. Aim of study: To investigate the anti-arthritic effects of Huangcaowu (AV). Materials and methods: Mono-arthritis in SD rats was induced by unilateral intra-articular injection of Freund's complete adjuvant. Physiological saline was injected in the contralateral knee. Seventy five percent ethanol extracts of AV (10 mg/kg/day and 100 mg/kg/day), AC (100 mg/kg/day) and AK (100 mg/kg/day) were administered to rats by oral gavage for 14 consecutive days (Day -6 to Day 7) while arthritis was induced at the seventh day (Day 0). The anti-arthritic effects of the herbs were assessed by measuring allodynia, swelling, hyperaemia and the vascular permeability of the knee joints. Results: AV (10 mg/kg/day and 100 mg/kg/day), AC (100 mg/kg/day) and AK (100 mg/kg/day) suppressed joint allodynia. AV (10 mg/kg/day and 100 mg/kg/day) and AK (100 mg/kg/day) significantly reduced join swelling and hyperaemia while AC (100 mg/kg/day) did not. AV (100 mg/kg/day) attenuated vascular permeability while AC (100 mg/kg/day) and AK (100 mg/kg/day) showed no improvement. Conclusions: Huangcaowu (AV) significantly improved allodynia, swelling, hyperaemia and vascular permeability in arthritic knee joints. It showed the highest anti-arthritic effects among the three tested Aconitum herbs.
机译：人种药理学相关性：乌头乌头（AC）和乌头乌头（AK）是两种通常用于治疗关节痛和关节炎的中药。在中国西南部，黄草乌（AV），是乌头乌头的根。长期以来一直被用作这些草药的局部替代品，用于止痛和抗炎。但是，尚未研究其抗关节炎作用。研究目的：探讨黄草伍的抗关节炎作用。材料与方法：单侧关节内注射弗氏完全佐剂可诱发SD大鼠单关节炎。在对侧膝盖注射生理盐水。通过口服管饲法将75％的AV（10 mg / kg /天和100 mg / kg /天），AC（100 mg / kg /天）和AK（100 mg / kg /天）乙醇提取物通过口服灌胃给予大鼠连续14天（第-6天到第7天），而在第七天（第0天）诱发关节炎。通过测量异常性疼痛，肿胀，充血和膝关节的血管通透性来评估草药的抗关节炎作用。结果：AV（10 mg / kg /天和100 mg / kg /天），AC（100 mg / kg /天）和AK（100 mg / kg /天）抑制关节异常性疼痛。 AV（10 mg / kg /天和100 mg / kg /天）和AK（100 mg / kg /天）显着降低了关节肿胀和充血，而AC（100 mg / kg /天）则没有。 AV（100 mg / kg / day）减弱了血管通透性，而AC（100 mg / kg / day）和AK（100 mg / kg / day）没有改善。结论：黄草ow明显改善了关节炎膝关节的异常性疼痛，肿胀，充血和血管通透性。在三种经测试的乌头草药中，它显示出最高的抗关节炎作用。

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