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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the beta-catenin pathway in colorectal cancer
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Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the beta-catenin pathway in colorectal cancer

机译:Chaga蘑菇(Inonotus obliquus)的麦角固醇过氧化物通过下调大肠癌中β-catenin途径表现出抗癌活性

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Aim of the study: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. Among them, one component showed the most effective growth inhibition and was identified as ergosterol peroxide by NMR analysis. We investigated the anti-proliferative and apoptosis mechanisms of ergosterol peroxide associated with its anti-cancer activities in human colorectal cancer (CRC) cell lines and tested its anti-tumor effect on colitis-induced CRC developed by Azoxymethane (AOM)/Dextran sulfate sodium (DSS) in a mouse model.
机译:研究目的:在这项研究中,我们检查了Chaga蘑菇(Inonotus Obliquus)的不同馏分和成分对结肠癌细胞的活力和凋亡的影响。其中,一种成分显示出最有效的生长抑制作用,并通过NMR分析鉴定为麦角固醇过氧化物。我们研究了麦角固醇过氧化物的抗增殖和凋亡机制及其在人结肠直肠癌(CRC)细胞系中的抗癌活性,并测试了其对由乙氧基甲烷(AOM)/右旋糖酐硫酸钠开发的结肠炎诱导的CRC的抗肿瘤作用(DSS)在鼠标模型中。

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