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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Yeast exposure in the preparation of steamed rehmannia root improving its effects on alloxan-induced diabetic rats
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Yeast exposure in the preparation of steamed rehmannia root improving its effects on alloxan-induced diabetic rats

机译：蒸熟地黄根制剂中的酵母暴露改善对四氧嘧啶致糖尿病大鼠的作用

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摘要

Ethnopharmacological relevance: The root of Rehmannia glutinosa (Gaertn.) DC. has been used in China for more than 2000 years to treat various diseases including diabetes mellitus (DM) and its complications. Steamed rehmannia root (SRR) is one of the mainly used forms. During its preparation, the material has the chance to be exposed to microorganisms, particularly yeast. The aim of this study is to verify the effect of SRR on diabetes complications and the necessity of yeast exposure. Materials and methods: Water extract of SRR was incubated with alcohol yeast to obtain fermented SRR (FSRR). Alloxan-induced diabetic rats were administrated with medicated animal chows for 8 weeks. Urine volume, fasted blood glucose and food intake were monitored, and open field test and tail immersion test were conducted in the last week, plasma and urine samples were subjected to biochemical examinations. Results: In DM rats, defecation in open field test was found reduced, and tail flick latency in tail immersion test increased. In the meantime, urinary excretions of Na+, K +, aldosterone, albumin and creatinine increased, and plasma concentrations of Na+, K+ and creatinine reduced and those of aldosterone, TXB2/6-Keto-PGF1α and urea nitrogen elevated. Most of these indicators were significantly improved by FSRR administration, but the effects of SRR were relatively inferior in several aspects. However, SRR and FSRR could not improve the typical symptoms of DM. Conclusions: Our data demonstrated that both SRR and FSRR have no obvious hypoglycemic effect, but have the potential to prevent the onset and development of diabetes complications, and this function can be improved by yeast exposure.
机译：民族药理学相关性：熟地黄（根）DC的根。在中国已使用2000多年，用于治疗各种疾病，包括糖尿病（DM）及其并发症。熟地黄（SRR）是最常用的形式之一。在制备过程中，该材料有机会接触微生物，特别是酵母。这项研究的目的是验证SRR对糖尿病并发症和酵母暴露的必要性的影响。材料和方法：将SRR的水提取物与酒精酵母一起孵育，以获得发酵的SRR（FSRR）。将四氧嘧啶诱导的糖尿病大鼠与药物动物饲料一起给药8周。监测尿量，空腹血糖和食物摄入，并在最后一周进行野外试验和尾巴浸没试验，对血浆和尿液样本进行生化检查。结果：在DM大鼠中，发现在野外试验中排便减少，并且在尾部浸没试验中甩尾潜伏期增加。同时，Na +，K +，醛固酮，白蛋白和肌酐的尿排泄增加，Na +，K +和肌酐的血浆浓度降低，醛固酮，TXB2 / 6-酮-PGF1α和尿素氮升高。 FSRR的使用显着改善了大多数这些指标，但SRR的效果在几个方面相对较差。但是，SRR和FSRR无法改善DM的典型症状。结论：我们的数据表明，SRR和FSRR均无明显的降血糖作用，但具有预防糖尿病并发症发作和发展的潜力，可以通过暴露酵母改善这种功能。

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