In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.

Jiwajinda S; Santisopasri V; Murakami A; Kawanaka M; Kawanaka H; Gasquet M; Eilas R; Balansard G; Ohigashi H

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In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.

机译：东南亚药用植物长生Eurycoma longifolia中的类胡萝卜素的体外抗肿瘤促进和抗寄生虫活性。

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Some quassinoids (1-6) isolated previously as plant growth inhibitors from the leaves of Eurycoma longifolia Jack. (Simaroubaceae) were subjected to in vitro tests on anti-tumor promoting, antischistosomal and plasmodicidal activities. The most active compound for inhibition of tumor promoter-induced Epstein-Barr virus activation (anti-tumor promotion) was 14,15beta-dihydroxyklaineanone (5, IC(50) = 5 microM). Longilactone (1) gave significant antischistosomal effect at a concentration of 200 microg/ml. 11-Dehydroklaineanone (3) and 15beta-O-acetyl-14-hydroxyklaineanone (6) showed potent plasmodicidal activity (IC(50) = 2 microg/ml). Thus it was suggested that E. longifolia possesses high medicinal values due to the occurrence of a variety of quassinoids.

机译：先前从长生杜仲叶中分离出一些作为植物生长抑制剂的类quassinoids（1-6）。（Simaroubaceae）进行了抗肿瘤促进，抗血吸虫和杀线虫活性的体外试验。抑制肿瘤启动子诱导的爱泼斯坦-巴尔病毒激活（抗肿瘤促进）的最有效化合物是14,15beta-dihydroxyklaineanone（5，IC（50）= 5 microM）。 Longilactone（1）在200微克/毫升的浓度下具有明显的抗血吸虫病作用。 11-脱氢角叉菜酮（3）和15beta-O-乙酰基-14-羟基角菜酮（6）显示出有效的杀血浆活性（IC（50）= 2 microg / ml）。因此，有人提出，由于多种类胡萝卜素的出现，长叶大肠杆菌具有很高的药用价值。

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《Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 |2002年第1期|共4页
作者
Jiwajinda S; Santisopasri V; Murakami A; Kawanaka M; Kawanaka H; Gasquet M; Eilas R; Balansard G; Ohigashi H;
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正文语种 eng
中图分类中药学;
关键词
quassin; Neoplasms; parasitic; /mL; ug; 肿瘤;

机译：quassin;Neoplasms;parasitic;/mL;ug;肿瘤;

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1. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. [J] . Jiwajinda S, Santisopasri V, Murakami A, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2002,第1期

机译：东南亚药用植物长生Eurycoma longifolia中的类胡萝卜素的体外抗肿瘤促进和抗寄生虫活性。
2. Characterization of the complete chloroplast genome of an important Southeast Asian medicinal plant, Eurycoma longifolia (Simaroubaceae) [J] . Wei Lun Ng, Shiou Yih Lee, Swee Keong Yeap Mitochondrial DNA Part B . 2019,第1期

机译：东南亚重要药用植物长叶Eryrycoma longifolia（Simaroubaceae）完整叶绿体基因组的特征
3. Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines [J] . Nguyen Huu Tung, Takuhiro Uto, Nguyen Thanh Hai, Pharmacognosy magazine . 2017,第51期

机译：长叶杜仲根中的类拟苦素及其对人癌细胞系的抗增殖活性
4. Anti-Tumor Activities of Extracts from the Medicinal Plants Pinellia ternata and Pinellia pedatisecta [C] . Juan Li, Keli Chen, Bi-sheng Huang, Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：药用半夏和半夏提取物的抗肿瘤活性
5. In vitro Antioxidant and Antibacterial Activity of Twenty-One Northern Ontario Medicinal Plants. [D] . Hassan, Mohammad Haider. 2013

机译：二十一种北安大略药用植物的体外抗氧化和抗菌活性。
6. The In Vitro and In Vivo Anti-Cancer Activities of a Standardized Quassinoids Composition from Eurycoma longifolia on LNCaP Human Prostate Cancer Cells [O] . Kind Leng Tong, Kit Lam Chan, Sazaly AbuBakar, -1

机译：一种标准的拟南芥中拟南芥类成分对LNCaP人前列腺癌细胞的体外和体内抗癌活性
7. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. [O] . Kind Leng Tong, Kit Lam Chan, Sazaly AbuBakar, 2015

机译：来自Eurycoma longifolia的标准化类胡萝卜素组合物对LNCap人前列腺癌细胞的体外和体内抗癌活性。

In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.

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